BRD-K69840642_HDAC6 inhibitor ISOX_SKMEL28_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADCY9 adenylate cyclase 9
AKAP13 A kinase (PRKA) anchor protein 13
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC3 baculoviral IAP repeat containing 3
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDND1 claudin domain containing 1
COL4A5 collagen, type IV, alpha 5
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNB2 ephrin-B2
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FNBP1L formin binding protein 1-like
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT57 intraflagellar transport 57
IL17RB interleukin 17 receptor B
IL32 interleukin 32
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
LDOC1 leucine zipper, down-regulated in cancer 1
LSR lipolysis stimulated lipoprotein receptor
MAOB monoamine oxidase B
MAST2 microtubule associated serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MN1 meningioma (disrupted in balanced translocation) 1
MX1 MX dynamin-like GTPase 1
MYBPC1 myosin binding protein C, slow type
NEB nebulin
NELL2 NEL-like 2 (chicken)
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PROM1 prominin 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBP1 retinol binding protein 1, cellular
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMYD3 SET and MYND domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAT1 signal transducer and activator of transcription 1, 91kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF4 transmembrane 4 L six family member 4
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ATF1 activating transcription factor 1
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
CAPN3 calpain 3, (p94)
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CELF2 CUGBP, Elav-like family member 2
CHL1 cell adhesion molecule L1-like
CLTC clathrin, heavy chain (Hc)
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GPNMB glycoprotein (transmembrane) nmb
GSTO1 glutathione S-transferase omega 1
GYG2 glycogenin 2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KEAP1 kelch-like ECH-associated protein 1
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LMNB1 lamin B1
LTF lactotransferrin
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFAP5 microfibrillar associated protein 5
MLANA melan-A
MLPH melanophilin
MOK MOK protein kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUSAP1 nucleolar and spindle associated protein 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP2 poly (ADP-ribose) polymerase 2
PDE4DIP phosphodiesterase 4D interacting protein
PLK1 polo-like kinase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSCA prostate stem cell antigen
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RTN4 reticulon 4
SCGB2A1 secretoglobin, family 2A, member 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SH3BP4 SH3-domain binding protein 4
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SNAI2 snail family zinc finger 2
SORD sorbitol dehydrogenase
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO3 small ubiquitin-like modifier 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VAT1 vesicle amine transport 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYND8 zinc finger, MYND-type containing 8