BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

263 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACAA1 acetyl-CoA acyltransferase 1
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
ARL3 ADP-ribosylation factor-like 3
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ASMTL acetylserotonin O-methyltransferase-like
BBX bobby sox homolog (Drosophila)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CCNG2 cyclin G2
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CPNE3 copine III
CREB3 cAMP responsive element binding protein 3
CRELD2 cysteine-rich with EGF-like domains 2
CSRP1 cysteine and glycine-rich protein 1
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCTN3 dynactin 3 (p22)
DES desmin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSTN destrin (actin depolymerizing factor)
DYNLT1 dynein, light chain, Tctex-type 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENAH enabled homolog (Drosophila)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FNBP1L formin binding protein 1-like
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GNS glucosamine (N-acetyl)-6-sulfatase
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HECA headcase homolog (Drosophila)
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H3H histone cluster 1, H3h
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
HSBP1 heat shock factor binding protein 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
LIMA1 LIM domain and actin binding 1
LRRN3 leucine rich repeat neuronal 3
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MEG3 maternally expressed 3 (non-protein coding)
MN1 meningioma (disrupted in balanced translocation) 1
MPZL1 myelin protein zero-like 1
MVP major vault protein
NCOA3 nuclear receptor coactivator 3
NEB nebulin
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRAF2 PRA1 domain family, member 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
SAR1A secretion associated, Ras related GTPase 1A
SCGB2A2 secretoglobin, family 2A, member 2
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
TKTL1 transketolase-like 1
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VAMP3 vesicle-associated membrane protein 3
WDR19 WD repeat domain 19
WDR47 WD repeat domain 47
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGAP15 Rho GTPase activating protein 15
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF1 activating transcription factor 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CD163 CD163 molecule
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CHD7 chromodomain helicase DNA binding protein 7
CLIC1 chloride intracellular channel 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COCH cochlin
CTGF connective tissue growth factor
CTSC cathepsin C
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EVI2B ecotropic viral integration site 2B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FAR2 fatty acyl CoA reductase 2
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FXYD5 FXYD domain containing ion transport regulator 5
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HHEX hematopoietically expressed homeobox
HOPX HOP homeobox
HOXA10 homeobox A10
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INTS3 integrator complex subunit 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KEAP1 kelch-like ECH-associated protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LAT2 linker for activation of T cells family, member 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LYZ lysozyme
MCTP1 multiple C2 domains, transmembrane 1
MGST2 microsomal glutathione S-transferase 2
MMP7 matrix metallopeptidase 7
MRPS30 mitochondrial ribosomal protein S30
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NOP16 NOP16 nucleolar protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NREP neuronal regeneration related protein
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARVB parvin, beta
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PLAC8 placenta-specific 8
PLEK pleckstrin
PODXL podocalyxin-like
PON2 paraoxonase 2
PRR7 proline rich 7 (synaptic)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF8 serine/arginine-rich splicing factor 8
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TESC tescalcin
TF transferrin
TNS3 tensin 3
TP53 tumor protein p53
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UFC1 ubiquitin-fold modifier conjugating enzyme 1
WIPF1 WAS/WASL interacting protein family, member 1
ZFP36L2 ZFP36 ring finger protein-like 2