BRD-K69840642_HDAC6 inhibitor ISOX_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGAP32 Rho GTPase activating protein 32
BICD2 bicaudal D homolog 2 (Drosophila)
C5AR1 complement component 5a receptor 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSV cathepsin V
CYBB cytochrome b-245, beta polypeptide
CYTH1 cytohesin 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DLK1 delta-like 1 homolog (Drosophila)
DSTN destrin (actin depolymerizing factor)
EDNRB endothelin receptor type B
ELN elastin
EMP2 epithelial membrane protein 2
ENOPH1 enolase-phosphatase 1
FHL1 four and a half LIM domains 1
FLNB filamin B, beta
FOXO4 forkhead box O4
GCA grancalcin, EF-hand calcium binding protein
GLRX glutaredoxin (thioltransferase)
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HIP1R huntingtin interacting protein 1 related
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSDL2 hydroxysteroid dehydrogenase like 2
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGSF3 immunoglobulin superfamily, member 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KIF1A kinesin family member 1A
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTA4H leukotriene A4 hydrolase
MEGF9 multiple EGF-like-domains 9
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MXRA7 matrix-remodelling associated 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OSTF1 osteoclast stimulating factor 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLS1 plastin 1
PSPH phosphoserine phosphatase
PTPRE protein tyrosine phosphatase, receptor type, E
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
RTN3 reticulon 3
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SKAP2 src kinase associated phosphoprotein 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRGN serglycin
STXBP1 syntaxin binding protein 1
TBPL1 TBP-like 1
THBS2 thrombospondin 2
TLE4 transducin-like enhancer of split 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAPPC4 trafficking protein particle complex 4
TRIM2 tripartite motif containing 2
VAT1 vesicle amine transport 1
WDR47 WD repeat domain 47
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOL3 apolipoprotein L, 3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CFB complement factor B
COG2 component of oligomeric golgi complex 2
COL4A6 collagen, type IV, alpha 6
CP ceruloplasmin (ferroxidase)
CST3 cystatin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DCTD dCMP deaminase
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPATCH8 G patch domain containing 8
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGA2 high mobility group AT-hook 2
IDO1 indoleamine 2,3-dioxygenase 1
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MDK midkine (neurite growth-promoting factor 2)
MEPCE methylphosphate capping enzyme
MMP10 matrix metallopeptidase 10
MSLN mesothelin
MSMB microseminoprotein, beta-
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPDC1 neural proliferation, differentiation and control, 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PSCA prostate stem cell antigen
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGCC regulator of cell cycle
RPL10 ribosomal protein L10
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFRP1 secreted frizzled-related protein 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD4 SMAD family member 4
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TFF1 trefoil factor 1
TLK1 tousled-like kinase 1
TM9SF3 transmembrane 9 superfamily member 3
TSC22D1 TSC22 domain family, member 1
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
WNT5A wingless-type MMTV integration site family, member 5A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2