BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADCY9 adenylate cyclase 9
AHCYL2 adenosylhomocysteinase-like 2
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
AMDHD2 amidohydrolase domain containing 2
ANO10 anoctamin 10
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASMTL acetylserotonin O-methyltransferase-like
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
CCNF cyclin F
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CISD1 CDGSH iron sulfur domain 1
CLDN10 claudin 10
CLEC2B C-type lectin domain family 2, member B
CPNE3 copine III
CPVL carboxypeptidase, vitellogenic-like
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GM2A GM2 ganglioside activator
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMG20B high mobility group 20B
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
IL1R2 interleukin 1 receptor, type II
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1X metallothionein 1X
MVP major vault protein
NEU1 sialidase 1 (lysosomal sialidase)
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLA2G15 phospholipase A2, group XV
PNMA2 paraneoplastic Ma antigen 2
POLB polymerase (DNA directed), beta
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRSS3 protease, serine, 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNAP29 synaptosomal-associated protein, 29kDa
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPX sushi-repeat containing protein, X-linked
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM14A transmembrane protein 14A
TMEM41B transmembrane protein 41B
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TYRP1 tyrosinase-related protein 1
UNC13B unc-13 homolog B (C. elegans)
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
APOA2 apolipoprotein A-II
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
C1QBP complement component 1, q subcomponent binding protein
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CD93 CD93 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CLEC11A C-type lectin domain family 11, member A
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CSK c-src tyrosine kinase
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCTD dCMP deaminase
DNM1L dynamin 1-like
EIF4A1 eukaryotic translation initiation factor 4A1
ELANE elastase, neutrophil expressed
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FXYD5 FXYD domain containing ion transport regulator 5
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
HDGF hepatoma-derived growth factor
HMGB2 high mobility group box 2
HOMER3 homer scaffolding protein 3
IARS isoleucyl-tRNA synthetase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
LAMP5 lysosomal-associated membrane protein family, member 5
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
LY6E lymphocyte antigen 6 complex, locus E
LYZ lysozyme
METTL7A methyltransferase like 7A
MICALL1 MICAL-like 1
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NKG7 natural killer cell granule protein 7
NMI N-myc (and STAT) interactor
NREP neuronal regeneration related protein
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAC8 placenta-specific 8
PLEK pleckstrin
PLK1 polo-like kinase 1
PRMT1 protein arginine methyltransferase 1
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RBMX RNA binding motif protein, X-linked
REPIN1 replication initiator 1
RGS4 regulator of G-protein signaling 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNH1 ribonuclease/angiogenin inhibitor 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX17 SRY (sex determining region Y)-box 17
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYK spleen tyrosine kinase
SYPL1 synaptophysin-like 1
TARP TCR gamma alternate reading frame protein
TEX10 testis expressed 10
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TRIM22 tripartite motif containing 22
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYMS thymidylate synthetase
UFC1 ubiquitin-fold modifier conjugating enzyme 1
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZYX zyxin