BRD-K69840642_HDAC6 inhibitor ISOX_OV7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAD8 acyl-CoA dehydrogenase family, member 8
ADAM10 ADAM metallopeptidase domain 10
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA3 annexin A3
ASRGL1 asparaginase like 1
ASS1 argininosuccinate synthase 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND3 cyclin D3
CD24 CD24 molecule
CD52 CD52 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK2 cyclin-dependent kinase 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENAH enabled homolog (Drosophila)
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS3 fatty acid desaturase 3
FBLN1 fibulin 1
FBLN5 fibulin 5
FBP1 fructose-1,6-bisphosphatase 1
FKBP14 FK506 binding protein 14, 22 kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FOXF1 forkhead box F1
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HIP1R huntingtin interacting protein 1 related
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IFI6 interferon, alpha-inducible protein 6
IRF8 interferon regulatory factor 8
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NEBL nebulette
NOSIP nitric oxide synthase interacting protein
NQO2 NAD(P)H dehydrogenase, quinone 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PLAC8 placenta-specific 8
PLS1 plastin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
REEP1 receptor accessory protein 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SGCE sarcoglycan, epsilon
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRGN serglycin
SST somatostatin
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TAC1 tachykinin, precursor 1
TBPL1 TBP-like 1
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WFDC1 WAP four-disulfide core domain 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ATF5 activating transcription factor 5
BHLHE40 basic helix-loop-helix family, member e40
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCND1 cyclin D1
COL1A2 collagen, type I, alpha 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
DST dystonin
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EREG epiregulin
ETV1 ets variant 1
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSCN1 fascin actin-bundling protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGLJ3 immunoglobulin lambda joining 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
ITGB1BP1 integrin beta 1 binding protein 1
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEPROT leptin receptor overlapping transcript
LY6D lymphocyte antigen 6 complex, locus D
LY96 lymphocyte antigen 96
MAPK6 mitogen-activated protein kinase 6
MET MET proto-oncogene, receptor tyrosine kinase
MLPH melanophilin
MYOF myoferlin
NBN nibrin
NOV nephroblastoma overexpressed
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OBSL1 obscurin-like 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PFN2 profilin 2
PRDX4 peroxiredoxin 4
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD23B RAD23 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SNAI2 snail family zinc finger 2
SNRPE small nuclear ribonucleoprotein polypeptide E
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TLK1 tousled-like kinase 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2