BRD-K69840642_HDAC6 inhibitor ISOX_NCIH508_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH508_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP29 Rho GTPase activating protein 29
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSG basigin (Ok blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFHD1 EF-hand domain family, member D1
ENAH enabled homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS2 fatty acid desaturase 2
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FAM46A family with sequence similarity 46, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRB7 growth factor receptor-bound protein 7
HAL histidine ammonia-lyase
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPIN1 lipin 1
MAGEB2 melanoma antigen family B2
METRN meteorin, glial cell differentiation regulator
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOSIP nitric oxide synthase interacting protein
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OPTN optineurin
OSTM1 osteopetrosis associated transmembrane protein 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN3 reticulon 3
SCPEP1 serine carboxypeptidase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRPX sushi-repeat containing protein, X-linked
STK17A serine/threonine kinase 17a
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBPL1 TBP-like 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TKTL1 transketolase-like 1
TOB1 transducer of ERBB2, 1
TRAK2 trafficking protein, kinesin binding 2
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VAT1 vesicle amine transport 1
VIM vimentin
VNN1 vanin 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADGRE5 adhesion G protein-coupled receptor E5
ADORA2B adenosine A2b receptor
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA3 annexin A3
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHD7 chromodomain helicase DNA binding protein 7
CIAPIN1 cytokine induced apoptosis inhibitor 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYC1 cytochrome c-1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
FABP4 fatty acid binding protein 4, adipocyte
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FBXO21 F-box protein 21
FERMT1 fermitin family member 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GPX2 glutathione peroxidase 2
GTPBP8 GTP-binding protein 8 (putative)
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KLF5 Kruppel-like factor 5 (intestinal)
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT14 keratin 14, type I
LAP3 leucine aminopeptidase 3
LCN2 lipocalin 2
LPL lipoprotein lipase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MRPS18B mitochondrial ribosomal protein S18B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCNA proliferating cell nuclear antigen
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PSCA prostate stem cell antigen
PUF60 poly-U binding splicing factor 60KDa
RAD23B RAD23 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS11 ribosomal protein S11
SLC35F2 solute carrier family 35, member F2
SLIT2 slit homolog 2 (Drosophila)
SLPI secretory leukocyte peptidase inhibitor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMBIM4 transmembrane BAX inhibitor motif containing 4
TNS3 tensin 3
TRIM29 tripartite motif containing 29
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TWF1 twinfilin actin binding protein 1
TYMS thymidylate synthetase
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38