BRD-K69840642_HDAC6 inhibitor ISOX_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

270 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACKR3 atypical chemokine receptor 3
ADCY9 adenylate cyclase 9
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
AQP1 aquaporin 1 (Colton blood group)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX4 brain expressed, X-linked 4
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CALD1 caldesmon 1
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CHMP2A charged multivesicular body protein 2A
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CTSV cathepsin V
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
EFCAB14 EF-hand calcium binding domain 14
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO1 forkhead box O1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
JAG1 jagged 1
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3
L1CAM L1 cell adhesion molecule
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LINC00094 long intergenic non-protein coding RNA 94
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
METRN meteorin, glial cell differentiation regulator
MSN moesin
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NRCAM neuronal cell adhesion molecule
OSBPL10 oxysterol binding protein-like 10
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB38 RAB38, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN2 reticulon 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNAI2 snail family zinc finger 2
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SST somatostatin
STAB1 stabilin 1
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UROD uroporphyrinogen decarboxylase
VAT1 vesicle amine transport 1
VWA5A von Willebrand factor A domain containing 5A
WBP1L WW domain binding protein 1-like
YPEL5 yippee-like 5 (Drosophila)
ZNF185 zinc finger protein 185 (LIM domain)
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ANXA10 annexin A10
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ATF5 activating transcription factor 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCLAF1 BCL2-associated transcription factor 1
BID BH3 interacting domain death agonist
C1QBP complement component 1, q subcomponent binding protein
CBFB core-binding factor, beta subunit
CCNE2 cyclin E2
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC25A cell division cycle 25A
COMT catechol-O-methyltransferase
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST3 cystatin C
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCTD dCMP deaminase
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DENND2D DENN/MADD domain containing 2D
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
ENO1 enolase 1, (alpha)
ENOSF1 enolase superfamily member 1
EXOSC4 exosome component 4
FAM111A family with sequence similarity 111, member A
FAM129A family with sequence similarity 129, member A
FANCL Fanconi anemia, complementation group L
FASN fatty acid synthase
FERMT1 fermitin family member 1
FGFR4 fibroblast growth factor receptor 4
FOSL1 FOS-like antigen 1
FPGS folylpolyglutamate synthase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GTPBP4 GTP binding protein 4
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IRAK1 interleukin-1 receptor-associated kinase 1
KANK1 KN motif and ankyrin repeat domains 1
KIAA0020 KIAA0020
KIAA0101 KIAA0101
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
LAD1 ladinin 1
LAT2 linker for activation of T cells family, member 2
LCN2 lipocalin 2
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBP myelin basic protein
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MRPS30 mitochondrial ribosomal protein S30
MRPS35 mitochondrial ribosomal protein S35
MSRA methionine sulfoxide reductase A
MTA1 metastasis associated 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBN nibrin
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
ODC1 ornithine decarboxylase 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB25 RAB25, member RAS oncogene family
RAN RAN, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RPL10 ribosomal protein L10
RPP40 ribonuclease P/MRP 40kDa subunit
RRM2 ribonucleotide reductase M2
RUFY3 RUN and FYVE domain containing 3
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFRC transferrin receptor
TMEM5 transmembrane protein 5
TMPO thymopoietin
TP53 tumor protein p53
TRA2B transformer 2 beta homolog (Drosophila)
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZBTB20 zinc finger and BTB domain containing 20
ZNF131 zinc finger protein 131