BRD-K69840642_HDAC6 inhibitor ISOX_HEC108_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BZW2 basic leucine zipper and W2 domains 2
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPB1 carboxypeptidase B1 (tissue)
CYB5R1 cytochrome b5 reductase 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DGKA diacylglycerol kinase, alpha 80kDa
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EHD3 EH-domain containing 3
F13A1 coagulation factor XIII, A1 polypeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA6 GATA binding protein 6
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HBB hemoglobin, beta
IDI1 isopentenyl-diphosphate delta isomerase 1
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NOSIP nitric oxide synthase interacting protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PLA2G15 phospholipase A2, group XV
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAP1GAP RAP1 GTPase activating protein
RECK reversion-inducing-cysteine-rich protein with kazal motifs
ROGDI rogdi homolog (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPT6 septin 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SOSTDC1 sclerostin domain containing 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSBP2 single-stranded DNA binding protein 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STX7 syntaxin 7
TBPL1 TBP-like 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
BIRC3 baculoviral IAP repeat containing 3
C6ORF62 chromosome 6 open reading frame 62
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COL18A1 collagen, type XVIII, alpha 1
COL6A2 collagen, type VI, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXA10 homeobox A10
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI35 interferon-induced protein 35
IGFBP1 insulin-like growth factor binding protein 1
IGKC immunoglobulin kappa constant
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCTP1 multiple C2 domains, transmembrane 1
MET MET proto-oncogene, receptor tyrosine kinase
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
OLFML2B olfactomedin-like 2B
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SFN stratifin
SLAMF7 SLAM family member 7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4
USP22 ubiquitin specific peptidase 22
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VWF von Willebrand factor
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38