BRD-K69840642_HDAC6 inhibitor ISOX_HCT116_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AACS acetoacetyl-CoA synthetase
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDOC aldolase C, fructose-bisphosphate
ALOX15B arachidonate 15-lipoxygenase, type B
ARL3 ADP-ribosylation factor-like 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C9ORF16 chromosome 9 open reading frame 16
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CHGB chromogranin B
CLDN3 claudin 3
CLTB clathrin, light chain B
CORO1B coronin, actin binding protein, 1B
CREG1 cellular repressor of E1A-stimulated genes 1
CYB5R1 cytochrome b5 reductase 1
DCTN3 dynactin 3 (p22)
DES desmin
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GALC galactosylceramidase
GDE1 glycerophosphodiester phosphodiesterase 1
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
GUK1 guanylate kinase 1
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
INHBA inhibin, beta A
IQCG IQ motif containing G
KCTD5 potassium channel tetramerization domain containing 5
KRT7 keratin 7, type II
MCOLN1 mucolipin 1
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP11 matrix metallopeptidase 11
MSRB1 methionine sulfoxide reductase B1
MUC2 mucin 2, oligomeric mucus/gel-forming
NCAM1 neural cell adhesion molecule 1
NME7 NME/NM23 family member 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PHKB phosphorylase kinase, beta
PITX1 paired-like homeodomain 1
PLA2G15 phospholipase A2, group XV
POR P450 (cytochrome) oxidoreductase
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAP1GAP RAP1 GTPase activating protein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SELENBP1 selenium binding protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A46 solute carrier family 25, member 46
SLC46A3 solute carrier family 46, member 3
SMTN smoothelin
SMYD3 SET and MYND domain containing 3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STK17A serine/threonine kinase 17a
STXBP1 syntaxin binding protein 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TPPP3 tubulin polymerization-promoting protein family member 3
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADM adrenomedullin
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANKRD10 ankyrin repeat domain 10
ATF1 activating transcription factor 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CA12 carbonic anhydrase XII
CASD1 CAS1 domain containing 1
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COCH cochlin
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
EREG epiregulin
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GEMIN4 gem (nuclear organelle) associated protein 4
HMGA2 high mobility group AT-hook 2
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXA10 homeobox A10
IFRD2 interferon-related developmental regulator 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IPO5 importin 5
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
LPAR1 lysophosphatidic acid receptor 1
LY96 lymphocyte antigen 96
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MET MET proto-oncogene, receptor tyrosine kinase
MRPL15 mitochondrial ribosomal protein L15
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
OXA1L oxidase (cytochrome c) assembly 1-like
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS3 plastin 3
PNN pinin, desmosome associated protein
PRMT1 protein arginine methyltransferase 1
PRPF4 pre-mRNA processing factor 4
PTX3 pentraxin 3, long
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDX radixin
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SENP6 SUMO1/sentrin specific peptidase 6
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SMAGP small cell adhesion glycoprotein
SNAI2 snail family zinc finger 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF11 serine/arginine-rich splicing factor 11
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGIF1 TGFB-induced factor homeobox 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB1 tribbles pseudokinase 1
TRIP6 thyroid hormone receptor interactor 6
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VCAN versican
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)