BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAK1 AP2 associated kinase 1
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASS1 argininosuccinate synthase 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLDN3 claudin 3
CLDND1 claudin domain containing 1
CRABP2 cellular retinoic acid binding protein 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
ENAH enabled homolog (Drosophila)
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP1A FK506 binding protein 1A, 12kDa
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GSN gelsolin
HECA headcase homolog (Drosophila)
HK1 hexokinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP5 insulin-like growth factor binding protein 5
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
JARID2 jumonji, AT rich interactive domain 2
KAZN kazrin, periplakin interacting protein
KIAA0226L KIAA0226-like
LIMA1 LIM domain and actin binding 1
LPIN1 lipin 1
LTA4H leukotriene A4 hydrolase
MAMLD1 mastermind-like domain containing 1
MARK4 MAP/microtubule affinity-regulating kinase 4
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLEC malectin
MLXIP MLX interacting protein
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OPTN optineurin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G15 phospholipase A2, group XV
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRKCD protein kinase C, delta
PSD3 pleckstrin and Sec7 domain containing 3
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RHCG Rh family, C glycoprotein
RND1 Rho family GTPase 1
S100A14 S100 calcium binding protein A14
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SSBP2 single-stranded DNA binding protein 2
STK17A serine/threonine kinase 17a
TBPL1 TBP-like 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TKT transketolase
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XYLT1 xylosyltransferase I
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADNP activity-dependent neuroprotector homeobox
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AREG amphiregulin
ARID1A AT rich interactive domain 1A (SWI-like)
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BICC1 BicC family RNA binding protein 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CFH complement factor H
COL5A2 collagen, type V, alpha 2
CREBBP CREB binding protein
CXCL2 chemokine (C-X-C motif) ligand 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
EBAG9 estrogen receptor binding site associated, antigen, 9
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
FAM60A family with sequence similarity 60, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FTH1 ferritin, heavy polypeptide 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GSPT2 G1 to S phase transition 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
HOXB7 homeobox B7
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KLF5 Kruppel-like factor 5 (intestinal)
KYNU kynureninase
LAMB1 laminin, beta 1
LCMT2 leucine carboxyl methyltransferase 2
LMNB1 lamin B1
LRRC17 leucine rich repeat containing 17
LRRC41 leucine rich repeat containing 41
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MECOM MDS1 and EVI1 complex locus
MRPS18B mitochondrial ribosomal protein S18B
MSLN mesothelin
MZT2A mitotic spindle organizing protein 2A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMI N-myc (and STAT) interactor
NPY1R neuropeptide Y receptor Y1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PDGFD platelet derived growth factor D
PER2 period circadian clock 2
PGLS 6-phosphogluconolactonase
PLK1 polo-like kinase 1
POGK pogo transposable element with KRAB domain
PON2 paraoxonase 2
PTX3 pentraxin 3, long
RAD54B RAD54 homolog B (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RGS1 regulator of G-protein signaling 1
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
SENP6 SUMO1/sentrin specific peptidase 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRY2 sprouty homolog 2 (Drosophila)
ST7 suppression of tumorigenicity 7
STEAP3 STEAP family member 3, metalloreductase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFDP1 transcription factor Dp-1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLK1 tousled-like kinase 1
TMEM5 transmembrane protein 5
TNS3 tensin 3
TSPAN8 tetraspanin 8
TUBGCP3 tubulin, gamma complex associated protein 3
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBQLN2 ubiquilin 2
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38
ZFP36L2 ZFP36 ring finger protein-like 2