BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

378 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
ADCY9 adenylate cyclase 9
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ARL3 ADP-ribosylation factor-like 3
ASMTL acetylserotonin O-methyltransferase-like
ASPH aspartate beta-hydroxylase
ATP10D ATPase, class V, type 10D
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATXN1 ataxin 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CPD carboxypeptidase D
CPVL carboxypeptidase, vitellogenic-like
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENAH enabled homolog (Drosophila)
EPPK1 epiplakin 1
EZR ezrin
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOXO4 forkhead box O4
G6PD glucose-6-phosphate dehydrogenase
GABARAPL2 GABA(A) receptor-associated protein-like 2
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR137B G protein-coupled receptor 137B
GSDMB gasdermin B
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
JARID2 jumonji, AT rich interactive domain 2
KLHL24 kelch-like family member 24
LBH limb bud and heart development
LGMN legumain
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NMT2 N-myristoyltransferase 2
NPC1 Niemann-Pick disease, type C1
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRAF2 PRA1 domain family, member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERINC3 serine incorporator 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SNN stannin
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBXA2R thromboxane A2 receptor
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM7SF2 transmembrane 7 superfamily member 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UBL3 ubiquitin-like 3
UBL5 ubiquitin-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCLAF1 BCL2-associated transcription factor 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFI complement factor I
CHEK1 checkpoint kinase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COMT catechol-O-methyltransferase
COPS3 COP9 signalosome subunit 3
COPS7A COP9 signalosome subunit 7A
CTPS1 CTP synthase 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCTD dCMP deaminase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EFS embryonal Fyn-associated substrate
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENOSF1 enolase superfamily member 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FAM111A family with sequence similarity 111, member A
FAM57A family with sequence similarity 57, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GEMIN4 gem (nuclear organelle) associated protein 4
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GSAP gamma-secretase activating protein
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HDGFRP3 hepatoma-derived growth factor, related protein 3
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HJURP Holliday junction recognition protein
HMGA1 high mobility group AT-hook 1
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXB2 homeobox B2
HOXB7 homeobox B7
HP haptoglobin
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLF4 Kruppel-like factor 4 (gut)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
LMNB1 lamin B1
LMNB2 lamin B2
LPL lipoprotein lipase
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MOCOS molybdenum cofactor sulfurase
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PFAS phosphoribosylformylglycinamidine synthase
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RFC3 replication factor C (activator 1) 3, 38kDa
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SFTPA2 surfactant protein A2
SHCBP1 SHC SH2-domain binding protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS3 sorbin and SH3 domain containing 3
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TEAD4 TEA domain family member 4
TFDP1 transcription factor Dp-1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMEM5 transmembrane protein 5
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TSPAN8 tetraspanin 8
TTK TTK protein kinase
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
VAV3 vav 3 guanine nucleotide exchange factor
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIF1 WNT inhibitory factor 1
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein