BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

385 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADCY2 adenylate cyclase 2 (brain)
ADCY9 adenylate cyclase 9
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG2 adhesion G protein-coupled receptor G2
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BLVRB biliverdin reductase B
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CALCA calcitonin-related polypeptide alpha
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPTM1 cleft lip and palate associated transmembrane protein 1
COBL cordon-bleu WH2 repeat protein
CPD carboxypeptidase D
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSF1R colony stimulating factor 1 receptor
CTR9 CTR9, Paf1/RNA polymerase II complex component
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FBXO2 F-box protein 2
FGFR4 fibroblast growth factor receptor 4
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP5 GTPase, IMAP family member 5
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
ITM2A integral membrane protein 2A
JAG1 jagged 1
JAK1 Janus kinase 1
JARID2 jumonji, AT rich interactive domain 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0513 KIAA0513
KIAA1598
KIF5C kinesin family member 5C
LBH limb bud and heart development
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPG lipase, endothelial
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTA4H leukotriene A4 hydrolase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1C1 mannosidase, alpha, class 1C, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MTUS1 microtubule associated tumor suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NMT2 N-myristoyltransferase 2
NPC1 Niemann-Pick disease, type C1
NPY1R neuropeptide Y receptor Y1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PALLD palladin, cytoskeletal associated protein
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDH17 protocadherin 17
PCDH9 protocadherin 9
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PGBD5 piggyBac transposable element derived 5
PLA2G15 phospholipase A2, group XV
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAP1GAP RAP1 GTPase activating protein
RB1CC1 RB1-inducible coiled-coil 1
REEP1 receptor accessory protein 1
RET ret proto-oncogene
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPHS2 selenophosphate synthetase 2
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIX1 SIX homeobox 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
STOM stomatin
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
THBD thrombomodulin
THEMIS2 thymocyte selection associated family member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLR2 toll-like receptor 2
TM7SF2 transmembrane 7 superfamily member 2
TNC tenascin C
TNIK TRAF2 and NCK interacting kinase
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
ZFP36 ZFP36 ring finger protein
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABR active BCR-related
ACAT2 acetyl-CoA acetyltransferase 2
ADAM12 ADAM metallopeptidase domain 12
ADCY7 adenylate cyclase 7
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNB2 cyclin B2
CCND1 cyclin D1
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CKAP4 cytoskeleton-associated protein 4
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COMT catechol-O-methyltransferase
CREB3L1 cAMP responsive element binding protein 3-like 1
CRELD2 cysteine-rich with EGF-like domains 2
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CYBRD1 cytochrome b reductase 1
CYTH1 cytohesin 1
DCTD dCMP deaminase
DEK DEK proto-oncogene
DERA deoxyribose-phosphate aldolase (putative)
DLC1 DLC1 Rho GTPase activating protein
DOCK10 dedicator of cytokinesis 10
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP3 dual specificity phosphatase 3
ECM1 extracellular matrix protein 1
ECT2 epithelial cell transforming 2
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
EIF5 eukaryotic translation initiation factor 5
EMP3 epithelial membrane protein 3
ENOSF1 enolase superfamily member 1
ERAP1 endoplasmic reticulum aminopeptidase 1
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FBN1 fibrillin 1
FBXO11 F-box protein 11
FERMT1 fermitin family member 1
FNDC3B fibronectin type III domain containing 3B
FOXM1 forkhead box M1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLIPR1 GLI pathogenesis-related 1
GRB10 growth factor receptor-bound protein 10
GREM2 gremlin 2, DAN family BMP antagonist
GTSE1 G-2 and S-phase expressed 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDDC2 HD domain containing 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL7R interleukin 7 receptor
ILF3 interleukin enhancer binding factor 3, 90kDa
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KLK11 kallikrein-related peptidase 11
KPNB1 karyopherin (importin) beta 1
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MOK MOK protein kinase
MPO myeloperoxidase
MSL1 male-specific lethal 1 homolog (Drosophila)
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OXTR oxytocin receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PFKL phosphofructokinase, liver
PGM1 phosphoglucomutase 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD23B RAD23 homolog B (S. cerevisiae)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SELE selectin E
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHCBP1 SHC SH2-domain binding protein 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SOX17 SRY (sex determining region Y)-box 17
SPRR3 small proline-rich protein 3
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STAG1 stromal antigen 1
STAG2 stromal antigen 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STMN1 stathmin 1
STXBP2 syntaxin binding protein 2
SUMO3 small ubiquitin-like modifier 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMELESS timeless circadian clock
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRA2B transformer 2 beta homolog (Drosophila)
TSPO translocator protein (18kDa)
TXN thioredoxin
TXNDC15 thioredoxin domain containing 15
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E1 ubiquitin-conjugating enzyme E2E 1
VBP1 von Hippel-Lindau binding protein 1
WFDC2 WAP four-disulfide core domain 2
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBED1 zinc finger, BED-type containing 1
ZBTB38 zinc finger and BTB domain containing 38
ZMYND11 zinc finger, MYND-type containing 11
ZWINT ZW10 interacting kinetochore protein