BRD-K69840642_HDAC6 inhibitor ISOX_H1299_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGAP29 Rho GTPase activating protein 29
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND3 cyclin D3
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN5 claudin 5
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
CPE carboxypeptidase E
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS3 fatty acid desaturase 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLM1 golgi membrane protein 1
GSTA4 glutathione S-transferase alpha 4
HECA headcase homolog (Drosophila)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IFNGR1 interferon gamma receptor 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCTD5 potassium channel tetramerization domain containing 5
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
MAOB monoamine oxidase B
MFAP4 microfibrillar-associated protein 4
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NAMPT nicotinamide phosphoribosyltransferase
NMU neuromedin U
OLFM1 olfactomedin 1
OPN3 opsin 3
PAX5 paired box 5
PCSK5 proprotein convertase subtilisin/kexin type 5
PEG10 paternally expressed 10
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RTN2 reticulon 2
SEPT6 septin 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNN stannin
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRGN serglycin
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TLE4 transducin-like enhancer of split 4
TMEM100 transmembrane protein 100
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
WASF1 WAS protein family, member 1
WFS1 Wolfram syndrome 1 (wolframin)
WLS wntless Wnt ligand secretion mediator
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGAP1 Rho GTPase activating protein 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BST2 bone marrow stromal cell antigen 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KLK11 kallikrein-related peptidase 11
LDLR low density lipoprotein receptor
LXN latexin
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
MSH6 mutS homolog 6
MUC16 mucin 16, cell surface associated
MYOF myoferlin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OBSL1 obscurin-like 1
OPHN1 oligophrenin 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PTPRO protein tyrosine phosphatase, receptor type, O
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TUG1 taurine up-regulated 1 (non-protein coding)
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP1 ubiquitin specific peptidase 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)