BRD-K69840642_HDAC6 inhibitor ISOX_DV90_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD3 abhydrolase domain containing 3
ACOT7 acyl-CoA thioesterase 7
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
AOX1 aldehyde oxidase 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CALCOCO2 calcium binding and coiled-coil domain 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCDC69 coiled-coil domain containing 69
CCND3 cyclin D3
CCNG2 cyclin G2
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
CYB5R1 cytochrome b5 reductase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
EAF2 ELL associated factor 2
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSTM3 glutathione S-transferase mu 3 (brain)
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFNGR1 interferon gamma receptor 1
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KDM5B lysine (K)-specific demethylase 5B
LGALS1 lectin, galactoside-binding, soluble, 1
LPIN1 lipin 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MICB MHC class I polypeptide-related sequence B
MMP1 matrix metallopeptidase 1
NOSIP nitric oxide synthase interacting protein
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAT ornithine aminotransferase
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTK2B protein tyrosine kinase 2 beta
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRGN serglycin
STOM stomatin
SYNGR3 synaptogyrin 3
TBPL1 TBP-like 1
TCF21 transcription factor 21
TCF4 transcription factor 4
TKTL1 transketolase-like 1
TOB1 transducer of ERBB2, 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADORA2B adenosine A2b receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
CCND1 cyclin D1
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CX3CL1 chemokine (C-X3-C motif) ligand 1
DCN decorin
DENND2D DENN/MADD domain containing 2D
DKC1 dyskeratosis congenita 1, dyskerin
EFS embryonal Fyn-associated substrate
F12 coagulation factor XII (Hageman factor)
FAM57A family with sequence similarity 57, member A
FKBP10 FK506 binding protein 10, 65 kDa
GPM6B glycoprotein M6B
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KEAP1 kelch-like ECH-associated protein 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPL lipoprotein lipase
LTF lactotransferrin
LUM lumican
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MCUR1 mitochondrial calcium uniporter regulator 1
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MFSD10 major facilitator superfamily domain containing 10
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PDGFC platelet derived growth factor C
PGLS 6-phosphogluconolactonase
PLK1 polo-like kinase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGES prostaglandin E synthase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAGP small cell adhesion glycoprotein
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRY2 sprouty homolog 2 (Drosophila)
STEAP3 STEAP family member 3, metalloreductase
STK10 serine/threonine kinase 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WEE1 WEE1 G2 checkpoint kinase
ZFP64 ZFP64 zinc finger protein
ZIC1 Zic family member 1