BRD-K69840642_HDAC6 inhibitor ISOX_CL34_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AMIGO2 adhesion molecule with Ig-like domain 2
ATXN1 ataxin 1
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CALD1 caldesmon 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CES1 carboxylesterase 1
CLU clusterin
COL5A2 collagen, type V, alpha 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FYN FYN proto-oncogene, Src family tyrosine kinase
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HAMP hepcidin antimicrobial peptide
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
ITM2A integral membrane protein 2A
LAPTM4B lysosomal protein transmembrane 4 beta
LINC00341 long intergenic non-protein coding RNA 341
LPIN2 lipin 2
MAGEA3 melanoma antigen family A3
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MEG3 maternally expressed 3 (non-protein coding)
MGP matrix Gla protein
NNMT nicotinamide N-methyltransferase
NRN1 neuritin 1
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PEG3 paternally expressed 3
PHACTR1 phosphatase and actin regulator 1
PHACTR2 phosphatase and actin regulator 2
RBP4 retinol binding protein 4, plasma
SEPT6 septin 6
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH2D1A SH2 domain containing 1A
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TDO2 tryptophan 2,3-dioxygenase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS3 transmembrane protease, serine 3
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIF1 WNT inhibitory factor 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
ADORA2B adenosine A2b receptor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATP10B ATPase, class V, type 10B
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
BOP1 block of proliferation 1
C1ORF106 chromosome 1 open reading frame 106
CANT1 calcium activated nucleotidase 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNB2 cyclin B2
CD320 CD320 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLTB clathrin, light chain B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CSRP2 cysteine and glycine-rich protein 2
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLD dihydrolipoamide dehydrogenase
DUOX2 dual oxidase 2
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPA33 glycoprotein A33 (transmembrane)
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
HSPA9 heat shock 70kDa protein 9 (mortalin)
IMP4 IMP4, U3 small nucleolar ribonucleoprotein
IPO13 importin 13
KLF5 Kruppel-like factor 5 (intestinal)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LONP1 lon peptidase 1, mitochondrial
LRP4 low density lipoprotein receptor-related protein 4
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MCM7 minichromosome maintenance complex component 7
MMP7 matrix metallopeptidase 7
MRPS35 mitochondrial ribosomal protein S35
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOP16 NOP16 nucleolar protein
OLFM4 olfactomedin 4
PCCB propionyl CoA carboxylase, beta polypeptide
PDIA6 protein disulfide isomerase family A, member 6
PDZK1IP1 PDZK1 interacting protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PON2 paraoxonase 2
PRDX2 peroxiredoxin 2
PRR7 proline rich 7 (synaptic)
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
QTRT1 queuine tRNA-ribosyltransferase 1
RFC2 replication factor C (activator 1) 2, 40kDa
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SMAGP small cell adhesion glycoprotein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRAPPC3 trafficking protein particle complex 3
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TXNL4A thioredoxin-like 4A
VDAC1 voltage-dependent anion channel 1