BRD-K69840642_HDAC6 inhibitor ISOX_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
AHCYL1 adenosylhomocysteinase-like 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP10A ATPase, class V, type 10A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN10 claudin 10
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CRLF1 cytokine receptor-like factor 1
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR7 7-dehydrocholesterol reductase
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EAF2 ELL associated factor 2
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM107A family with sequence similarity 107, member A
FBLN5 fibulin 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPX3 glutathione peroxidase 3
GSN gelsolin
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK1 hexokinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIF5C kinesin family member 5C
LGALS1 lectin, galactoside-binding, soluble, 1
MAMLD1 mastermind-like domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PRAF2 PRA1 domain family, member 2
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PSENEN presenilin enhancer gamma secretase subunit
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RECK reversion-inducing-cysteine-rich protein with kazal motifs
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SST somatostatin
STXBP1 syntaxin binding protein 1
TACC1 transforming, acidic coiled-coil containing protein 1
TBPL1 TBP-like 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VNN1 vanin 1
WDR47 WD repeat domain 47
WDR61 WD repeat domain 61
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
ARID1A AT rich interactive domain 1A (SWI-like)
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CKAP4 cytoskeleton-associated protein 4
COA3 cytochrome c oxidase assembly factor 3
CXCL14 chemokine (C-X-C motif) ligand 14
DCTD dCMP deaminase
DENND2D DENN/MADD domain containing 2D
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
GOSR1 golgi SNAP receptor complex member 1
GSAP gamma-secretase activating protein
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
LRRC41 leucine rich repeat containing 41
MAPK13 mitogen-activated protein kinase 13
MICALL1 MICAL-like 1
MRPL57 mitochondrial ribosomal protein L57
MRPS18B mitochondrial ribosomal protein S18B
MTA1 metastasis associated 1
NCOR2 nuclear receptor corepressor 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RCN1 reticulocalbin 1, EF-hand calcium binding domain
REPIN1 replication initiator 1
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SENP6 SUMO1/sentrin specific peptidase 6
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNRPE small nuclear ribonucleoprotein polypeptide E
SOCS2 suppressor of cytokine signaling 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TLK2 tousled-like kinase 2
TMEM109 transmembrane protein 109
TNNC1 troponin C type 1 (slow)
TRIM29 tripartite motif containing 29
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3H4 zinc finger CCCH-type containing 4
ZNF512B zinc finger protein 512B
Funding