BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACOT7 acyl-CoA thioesterase 7
ADCY9 adenylate cyclase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALAD aminolevulinate dehydratase
ALDOC aldolase C, fructose-bisphosphate
ANKRD46 ankyrin repeat domain 46
ANXA6 annexin A6
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AVIL advillin
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CTH cystathionine gamma-lyase
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FABP1 fatty acid binding protein 1, liver
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FBP1 fructose-1,6-bisphosphatase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GM2A GM2 ganglioside activator
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GSN gelsolin
HECA headcase homolog (Drosophila)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
INSIG1 insulin induced gene 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIAA1033 KIAA1033
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LIMA1 LIM domain and actin binding 1
LPIN1 lipin 1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MBNL2 muscleblind-like splicing regulator 2
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLEC malectin
MLF1 myeloid leukemia factor 1
MPC1 mitochondrial pyruvate carrier 1
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
MZB1 marginal zone B and B1 cell-specific protein
NANS N-acetylneuraminic acid synthase
NDRG1 N-myc downstream regulated 1
NEFM neurofilament, medium polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OAT ornithine aminotransferase
OSBPL8 oxysterol binding protein-like 8
OSTF1 osteoclast stimulating factor 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN2 perilipin 2
POLB polymerase (DNA directed), beta
PROM1 prominin 1
PRSS2 protease, serine, 2 (trypsin 2)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTTG1IP pituitary tumor-transforming 1 interacting protein
RAD9A RAD9 homolog A (S. pombe)
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RIMS3 regulating synaptic membrane exocytosis 3
ROGDI rogdi homolog (Drosophila)
RRBP1 ribosome binding protein 1
RTN2 reticulon 2
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNN stannin
SORT1 sortilin 1
SPAG9 sperm associated antigen 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
STAB1 stabilin 1
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STK38 serine/threonine kinase 38
STXBP1 syntaxin binding protein 1
TBC1D4 TBC1 domain family, member 4
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VAMP7 vesicle-associated membrane protein 7
VAT1 vesicle amine transport 1
VCL vinculin
WDR47 WD repeat domain 47
WDTC1 WD and tetratricopeptide repeats 1
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ARGLU1 arginine and glutamate rich 1
ARL4A ADP-ribosylation factor-like 4A
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EREG epiregulin
EXOSC4 exosome component 4
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSAP gamma-secretase activating protein
HMBS hydroxymethylbilane synthase
HMGB2 high mobility group box 2
HOXA10 homeobox A10
HOXB7 homeobox B7
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP6 insulin-like growth factor binding protein 6
ILF3 interleukin enhancer binding factor 3, 90kDa
JADE2 jade family PHD finger 2
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LHX2 LIM homeobox 2
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
METTL3 methyltransferase like 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MRPL15 mitochondrial ribosomal protein L15
MTA1 metastasis associated 1
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
PDCD2 programmed cell death 2
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PFAS phosphoribosylformylglycinamidine synthase
PFDN4 prefoldin subunit 4
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PON2 paraoxonase 2
PTX3 pentraxin 3, long
PUS7 pseudouridylate synthase 7 (putative)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIN2 Ras and Rab interactor 2
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SFRP1 secreted frizzled-related protein 1
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMX1 thioredoxin-related transmembrane protein 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TP53I3 tumor protein p53 inducible protein 3
TRD T cell receptor delta locus
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB20 zinc finger and BTB domain containing 20
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF532 zinc finger protein 532