BRD-K69181860_arg-csc-91_SKLU1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K69181860_arg-csc-91_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
ALB albumin
AQP1 aquaporin 1 (Colton blood group)
ATP11B ATPase, class VI, type 11B
BACE2 beta-site APP-cleaving enzyme 2
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CCND2 cyclin D2
CD200 CD200 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA2 chloride channel accessory 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTSV cathepsin V
DSC3 desmocollin 3
DSG3 desmoglein 3
ELN elastin
EPAS1 endothelial PAS domain protein 1
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRAMD1C GRAM domain containing 1C
HBB hemoglobin, beta
HEBP1 heme binding protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGL immunoglobulin lambda locus
IGSF3 immunoglobulin superfamily, member 3
IL1RN interleukin 1 receptor antagonist
ISOC1 isochorismatase domain containing 1
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK8 kallikrein-related peptidase 8
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LBH limb bud and heart development
LDOC1 leucine zipper, down-regulated in cancer 1
LY6D lymphocyte antigen 6 complex, locus D
LYPD3 LY6/PLAUR domain containing 3
MN1 meningioma (disrupted in balanced translocation) 1
MPZL2 myelin protein zero-like 2
MX1 MX dynamin-like GTPase 1
NPEPL1 aminopeptidase-like 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSG1 neuron specific gene family member 1
OBSL1 obscurin-like 1
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRK protein tyrosine phosphatase, receptor type, K
RBP1 retinol binding protein 1, cellular
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP1 secreted frizzled-related protein 1
SLPI secretory leukocyte peptidase inhibitor
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM4SF1 transmembrane 4 L six family member 1
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TRPS1 trichorhinophalangeal syndrome I
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADI1 acireductone dioxygenase 1
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CCDC86 coiled-coil domain containing 86
CD99 CD99 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CLCA1 chloride channel accessory 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBN1 fibrillin 1
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IRS2 insulin receptor substrate 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO4 LIM domain only 4
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MED1 mediator complex subunit 1
NAV3 neuron navigator 3
NRIP1 nuclear receptor interacting protein 1
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAT plasminogen activator, tissue
PNMA1 paraneoplastic Ma antigen 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB5C RAB5C, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAC3D1 SAC3 domain containing 1
SEPT11 septin 11
SF1 splicing factor 1
SFPQ splicing factor proline/glutamine-rich
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMP4 TIMP metallopeptidase inhibitor 4
TLR4 toll-like receptor 4
TM9SF3 transmembrane 9 superfamily member 3
TWIST1 twist family bHLH transcription factor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB38 zinc finger and BTB domain containing 38
ZFAND5 zinc finger, AN1-type domain 5