BRD-K69181860_arg-csc-91_RKO_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K69181860_arg-csc-91_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACOX2 acyl-CoA oxidase 2, branched chain
ADAMDEC1 ADAM-like, decysin 1
ALOX15B arachidonate 15-lipoxygenase, type B
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
BTG2 BTG family, member 2
CA1 carbonic anhydrase I
CADM1 cell adhesion molecule 1
CD1E CD1e molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CECR1 cat eye syndrome chromosome region, candidate 1
CEP57 centrosomal protein 57kDa
CHGB chromogranin B
CHMP4A charged multivesicular body protein 4A
CLEC10A C-type lectin domain family 10, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CST1 cystatin SN
CTSH cathepsin H
CXCL9 chemokine (C-X-C motif) ligand 9
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND1B DENN/MADD domain containing 1B
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECHDC3 enoyl CoA hydratase domain containing 3
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
FBXL12 F-box and leucine-rich repeat protein 12
FBXO21 F-box protein 21
FHOD3 formin homology 2 domain containing 3
FRY furry homolog (Drosophila)
FST follistatin
FZD7 frizzled class receptor 7
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
H2AFV H2A histone family, member V
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGSF3 immunoglobulin superfamily, member 3
INHBA inhibin, beta A
IPO13 importin 13
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD12 potassium channel tetramerization domain containing 12
LRP2 low density lipoprotein receptor-related protein 2
LYZ lysozyme
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NEBL nebulette
NEFL neurofilament, light polypeptide
NID1 nidogen 1
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ORC1 origin recognition complex, subunit 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCP4 Purkinje cell protein 4
PKP2 plakophilin 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCL1 phospholipase C-like 1
PLN phospholamban
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPOX protoporphyrinogen oxidase
PRUNE prune exopolyphosphatase
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIRPA signal-regulatory protein alpha
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST18 suppression of tumorigenicity 18, zinc finger
STAB1 stabilin 1
STON1 stonin 1
SULF1 sulfatase 1
TMEM30B transmembrane protein 30B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADGRG6 adhesion G protein-coupled receptor G6
AKAP7 A kinase (PRKA) anchor protein 7
ANKRD10 ankyrin repeat domain 10
ANXA5 annexin A5
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIN1 bridging integrator 1
CAPNS1 calpain, small subunit 1
CAST calpastatin
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHL1 cell adhesion molecule L1-like
CRISP3 cysteine-rich secretory protein 3
CSRP1 cysteine and glycine-rich protein 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP10 dual specificity phosphatase 10
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134C family with sequence similarity 134, member C
FKBP11 FK506 binding protein 11, 19 kDa
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GOLT1B golgi transport 1B
HBB hemoglobin, beta
HOXA10 homeobox A10
IFITM2 interferon induced transmembrane protein 2
IGKV4-1 immunoglobulin kappa variable 4-1
KRT10 keratin 10, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAMLD1 mastermind-like domain containing 1
MAP2K3 mitogen-activated protein kinase kinase 3
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
MSX1 msh homeobox 1
MYO6 myosin VI
NAMPT nicotinamide phosphoribosyltransferase
NUP210 nucleoporin 210kDa
PCDH9 protocadherin 9
PI3 peptidase inhibitor 3, skin-derived
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
R3HDM4 R3H domain containing 4
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPL27A ribosomal protein L27a
RPL36 ribosomal protein L36
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
STK39 serine threonine kinase 39
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TRIP6 thyroid hormone receptor interactor 6
TSPO translocator protein (18kDa)
UGCG UDP-glucose ceramide glucosyltransferase
YBX3 Y box binding protein 3