BRD-K69159985_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K69159985_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASPN asporin
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CALD1 caldesmon 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
CTSK cathepsin K
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ESR1 estrogen receptor 1
EVI2A ecotropic viral integration site 2A
FBLN1 fibulin 1
FBN2 fibrillin 2
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
HIST1H2AC histone cluster 1, H2ac
HTRA1 HtrA serine peptidase 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
IPO13 importin 13
KIAA0753 KIAA0753
LGALS4 lectin, galactoside-binding, soluble, 4
LOXL1 lysyl oxidase-like 1
LRRC15 leucine rich repeat containing 15
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCF4 neutrophil cytosolic factor 4, 40kDa
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH1 notch 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PLVAP plasmalemma vesicle associated protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SULF1 sulfatase 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TRIM2 tripartite motif containing 2
WISP2 WNT1 inducible signaling pathway protein 2
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C2 aldo-keto reductase family 1, member C2
APLP2 amyloid beta (A4) precursor-like protein 2
C6ORF62 chromosome 6 open reading frame 62
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP4A charged multivesicular body protein 4A
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FHL2 four and a half LIM domains 2
GCLM glutamate-cysteine ligase, modifier subunit
GRIA2 glutamate receptor, ionotropic, AMPA 2
HEBP1 heme binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
MMP7 matrix metallopeptidase 7
PLAC8 placenta-specific 8
REEP1 receptor accessory protein 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCD5 stearoyl-CoA desaturase 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
UBE2S ubiquitin-conjugating enzyme E2S