BRD-K68336408_Tyrphostin AG 1478_A549_6.0_h_56.78_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

212 genes differentially expressed following the BRD-K68336408_Tyrphostin AG 1478_A549_6.0_h_56.78_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
APOD apolipoprotein D
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALU calumenin
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COL9A3 collagen, type IX, alpha 3
COPA coatomer protein complex, subunit alpha
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK9 dedicator of cytokinesis 9
DUSP6 dual specificity phosphatase 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FBP1 fructose-1,6-bisphosphatase 1
FKBP11 FK506 binding protein 11, 19 kDa
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLS glutaminase
GOLGB1 golgin B1
GPX4 glutathione peroxidase 4
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBE inhibin, beta E
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
MAGEA3 melanoma antigen family A3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MTSS1 metastasis suppressor 1
NANS N-acetylneuraminic acid synthase
NAV2 neuron navigator 2
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDIA5 protein disulfide isomerase family A, member 5
PHGDH phosphoglycerate dehydrogenase
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PRODH proline dehydrogenase (oxidase) 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC31A SEC31 homolog A (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SFTPB surfactant protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC22A18 solute carrier family 22, member 18
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPRB signal recognition particle receptor, B subunit
STC2 stanniocalcin 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UFM1 ubiquitin-fold modifier 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCHE butyrylcholinesterase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CCND3 cyclin D3
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CLTB clathrin, light chain B
CLU clusterin
COG7 component of oligomeric golgi complex 7
COL4A6 collagen, type IV, alpha 6
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
FJX1 four jointed box 1 (Drosophila)
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FYB FYN binding protein
GALC galactosylceramidase
GCLC glutamate-cysteine ligase, catalytic subunit
GLIPR1 GLI pathogenesis-related 1
GMPR guanosine monophosphate reductase
GPX3 glutathione peroxidase 3
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
KEAP1 kelch-like ECH-associated protein 1
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MEIS2 Meis homeobox 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOB1A MOB kinase activator 1A
NAV3 neuron navigator 3
NOP16 NOP16 nucleolar protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NUP62 nucleoporin 62kDa
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
PON2 paraoxonase 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM12 RNA binding motif protein 12
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SNRPE small nuclear ribonucleoprotein polypeptide E
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TRIM14 tripartite motif containing 14
TRIM16 tripartite motif containing 16
UPK1B uroplakin 1B
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1