BRD-K68185022_Ursolic Acid_VCAP_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K68185022_Ursolic Acid_VCAP_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
C10ORF10 chromosome 10 open reading frame 10
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CCNG2 cyclin G2
CCR2 chemokine (C-C motif) receptor 2
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FN1 fibronectin 1
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL32 interleukin 32
INSIG1 insulin induced gene 1
JUNB jun B proto-oncogene
LAMB3 laminin, beta 3
LDLR low density lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
NAMPT nicotinamide phosphoribosyltransferase
NFE2L3 nuclear factor, erythroid 2-like 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRDX2 peroxiredoxin 2
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
TAPBP TAP binding protein (tapasin)
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADCY7 adenylate cyclase 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CP ceruloplasmin (ferroxidase)
CTSG cathepsin G
GALC galactosylceramidase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HSPA2 heat shock 70kDa protein 2
IFI27 interferon, alpha-inducible protein 27
IFITM2 interferon induced transmembrane protein 2
MCAM melanoma cell adhesion molecule
MFSD10 major facilitator superfamily domain containing 10
NYNRIN NYN domain and retroviral integrase containing
PFN2 profilin 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RBP1 retinol binding protein 1, cellular
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SPARCL1 SPARC-like 1 (hevin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSFA2 sperm specific antigen 2
TSPAN8 tetraspanin 8
WT1 Wilms tumor 1