BRD-K68185022_Ursolic Acid_VCAP_24.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K68185022_Ursolic Acid_VCAP_24.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACPP acid phosphatase, prostate
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL2 chemokine (C-C motif) ligand 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L2 chitinase 3-like 2
CLDN3 claudin 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EDNRB endothelin receptor type B
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FOXO3 forkhead box O3
FZD5 frizzled class receptor 5
HBB hemoglobin, beta
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF167 ring finger protein 167
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SMAD7 SMAD family member 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
APP amyloid beta (A4) precursor protein
B3GNT1
CTSG cathepsin G
DEGS1 delta(4)-desaturase, sphingolipid 1
ECI2 enoyl-CoA delta isomerase 2
GPX1 glutathione peroxidase 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
THBS1 thrombospondin 1
TSPAN4 tetraspanin 4
UBE2G2 ubiquitin-conjugating enzyme E2G 2