BRD-K68185022_Ursolic Acid_PL21_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K68185022_Ursolic Acid_PL21_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALB albumin
ALOX5 arachidonate 5-lipoxygenase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CCNA1 cyclin A1
CCNG2 cyclin G2
CD86 CD86 molecule
CD99 CD99 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CNPY3 canopy FGF signaling regulator 3
COL14A1 collagen, type XIV, alpha 1
COL15A1 collagen, type XV, alpha 1
CTTN cortactin
DAXX death-domain associated protein
DCLK1 doublecortin-like kinase 1
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
EIF1B eukaryotic translation initiation factor 1B
ENAH enabled homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERAP2 endoplasmic reticulum aminopeptidase 2
EVI2A ecotropic viral integration site 2A
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FAM69A family with sequence similarity 69, member A
FAP fibroblast activation protein, alpha
GAGE3 G antigen 3
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPNMB glycoprotein (transmembrane) nmb
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB6 homeobox B6
HOXC6 homeobox C6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCF2 neutrophil cytosolic factor 2
NDP Norrie disease (pseudoglioma)
NID1 nidogen 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSR2 odd-skipped related transciption factor 2
PALLD palladin, cytoskeletal associated protein
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
RB1CC1 RB1-inducible coiled-coil 1
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RNF167 ring finger protein 167
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SHOX2 short stature homeobox 2
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SQLE squalene epoxidase
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SYBU syntabulin (syntaxin-interacting)
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADI1 acireductone dioxygenase 1
AK2 adenylate kinase 2
AK4 adenylate kinase 4
AZU1 azurocidin 1
BEX1 brain expressed, X-linked 1
BST2 bone marrow stromal cell antigen 2
CCND2 cyclin D2
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COCH cochlin
CTSG cathepsin G
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FAM162A family with sequence similarity 162, member A
FAM216A family with sequence similarity 216, member A
FBN2 fibrillin 2
FIBP fibroblast growth factor (acidic) intracellular binding protein
GINS2 GINS complex subunit 2 (Psf2 homolog)
HES1 hes family bHLH transcription factor 1
ICMT isoprenylcysteine carboxyl methyltransferase
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT5 keratin 5, type II
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYB v-myb avian myeloblastosis viral oncogene homolog
NIT2 nitrilase family, member 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCCB propionyl CoA carboxylase, beta polypeptide
PENK proenkephalin
PLAC8 placenta-specific 8
S100A2 S100 calcium binding protein A2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35B1 solute carrier family 35, member B1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TOR1A torsin family 1, member A (torsin A)
TSPYL5 TSPY-like 5
UBE3C ubiquitin protein ligase E3C
UGCG UDP-glucose ceramide glucosyltransferase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF586 zinc finger protein 586