BRD-K68185022_Ursolic Acid_PC3_24.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K68185022_Ursolic Acid_PC3_24.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
BLVRB biliverdin reductase B
BMP2 bone morphogenetic protein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRISP3 cysteine-rich secretory protein 3
CTH cystathionine gamma-lyase
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FADS1 fatty acid desaturase 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
INSIG1 insulin induced gene 1
KLF5 Kruppel-like factor 5 (intestinal)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP1 matrix metallopeptidase 1
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RIOK3 RIO kinase 3
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRGN serglycin
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
CDC25A cell division cycle 25A
CTPS1 CTP synthase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DICER1 dicer 1, ribonuclease type III
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GLIPR1 GLI pathogenesis-related 1
MCM6 minichromosome maintenance complex component 6
MRPS30 mitochondrial ribosomal protein S30
MYH10 myosin, heavy chain 10, non-muscle
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PTDSS1 phosphatidylserine synthase 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
SRSF7 serine/arginine-rich splicing factor 7
TMPO thymopoietin
UNG uracil-DNA glycosylase