BRD-K68185022_Ursolic Acid_LOVO_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K68185022_Ursolic Acid_LOVO_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
AKR1C3 aldo-keto reductase family 1, member C3
ANXA1 annexin A1
ANXA10 annexin A10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CIRBP cold inducible RNA binding protein
CLDN18 claudin 18
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CPA3 carboxypeptidase A3 (mast cell)
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSE cathepsin E
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
EIF5A eukaryotic translation initiation factor 5A
EVI2A ecotropic viral integration site 2A
FADS2 fatty acid desaturase 2
FBN1 fibrillin 1
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOSL2 FOS-like antigen 2
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAS GNAS complex locus
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IPO13 importin 13
JAG1 jagged 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT20 keratin 20, type I
KRT7 keratin 7, type II
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCTP1 multiple C2 domains, transmembrane 1
MFAP5 microfibrillar associated protein 5
MPO myeloperoxidase
MT1G metallothionein 1G
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PHYH phytanoyl-CoA 2-hydroxylase
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
PPOX protoporphyrinogen oxidase
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTX3 pentraxin 3, long
QKI QKI, KH domain containing, RNA binding
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RHAG Rh-associated glycoprotein
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
SRGN serglycin
SULF1 sulfatase 1
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TRPS1 trichorhinophalangeal syndrome I
VCAN versican
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG2 adhesion G protein-coupled receptor G2
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
BPIFA1 BPI fold containing family A, member 1
C1R complement component 1, r subcomponent
CBR1 carbonyl reductase 1
CCND1 cyclin D1
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC42 cell division cycle 42
CES1 carboxylesterase 1
CLU clusterin
CP ceruloplasmin (ferroxidase)
CSK c-src tyrosine kinase
FABP7 fatty acid binding protein 7, brain
FAM46A family with sequence similarity 46, member A
FUS FUS RNA binding protein
GRWD1 glutamate-rich WD repeat containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HN1L hematological and neurological expressed 1-like
HP haptoglobin
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPB8 heat shock 22kDa protein 8
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGKV1-5 immunoglobulin kappa variable 1-5
KRT10 keratin 10, type I
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEF1 lymphoid enhancer-binding factor 1
LY75 lymphocyte antigen 75
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MPZL1 myelin protein zero-like 1
MSRB1 methionine sulfoxide reductase B1
MYCBP MYC binding protein
MYO1B myosin IB
NAAA N-acylethanolamine acid amidase
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
OPN3 opsin 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAX5 paired box 5
PDLIM2 PDZ and LIM domain 2 (mystique)
PGK1 phosphoglycerate kinase 1
PHB prohibitin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPL periplakin
PRF1 perforin 1 (pore forming protein)
PTDSS1 phosphatidylserine synthase 1
RANBP6 RAN binding protein 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPT6 septin 6
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMYD2 SET and MYND domain containing 2
SNX11 sorting nexin 11
SORBS2 sorbin and SH3 domain containing 2
SORD sorbitol dehydrogenase
SRSF7 serine/arginine-rich splicing factor 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGM2 transglutaminase 2
TMPO thymopoietin
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)