BRD-K68185022_Ursolic Acid_HA1E_6.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K68185022_Ursolic Acid_HA1E_6.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FAM107A family with sequence similarity 107, member A
FAR2 fatty acyl CoA reductase 2
FBN2 fibrillin 2
FOXJ3 forkhead box J3
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HIRA histone cell cycle regulator
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLIN2 perilipin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS8 protease, serine, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RRAD Ras-related associated with diabetes
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK3 SIK family kinase 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
THBS2 thrombospondin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPSAB1 tryptase alpha/beta 1
TRD T cell receptor delta locus
TRIB3 tribbles pseudokinase 3
TWIST1 twist family bHLH transcription factor 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABHD2 abhydrolase domain containing 2
ACACA acetyl-CoA carboxylase alpha
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BLCAP bladder cancer associated protein
CAST calpastatin
CBR4 carbonyl reductase 4
CBX5 chromobox homolog 5
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CHL1 cell adhesion molecule L1-like
COCH cochlin
CYTH1 cytohesin 1
DDHD2 DDHD domain containing 2
DICER1 dicer 1, ribonuclease type III
DPYSL3 dihydropyrimidinase-like 3
DUSP3 dual specificity phosphatase 3
EFCAB14 EF-hand calcium binding domain 14
FAM208A family with sequence similarity 208, member A
FBLN1 fibulin 1
FBXW2 F-box and WD repeat domain containing 2
FLNB filamin B, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GOLGA8A golgin A8 family, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HDAC1 histone deacetylase 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXC6 homeobox C6
ICMT isoprenylcysteine carboxyl methyltransferase
KIAA0907 KIAA0907
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUC7L3 LUC7-like 3 (S. cerevisiae)
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MATN2 matrilin 2
MCM3 minichromosome maintenance complex component 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MREG melanoregulin
MYLK myosin light chain kinase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCYOX1 prenylcysteine oxidase 1
PCYOX1L prenylcysteine oxidase 1 like
PFN2 profilin 2
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNISR PNN-interacting serine/arginine-rich protein
PNN pinin, desmosome associated protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PURA purine-rich element binding protein A
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP4 retinoblastoma binding protein 4
RBP1 retinol binding protein 1, cellular
RHOBTB3 Rho-related BTB domain containing 3
RSRP1 arginine/serine-rich protein 1
RUNX1 runt-related transcription factor 1
SKP1 S-phase kinase-associated protein 1
SLC35E2B solute carrier family 35, member E2B
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNX11 sorting nexin 11
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
SRSF11 serine/arginine-rich splicing factor 11
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TARDBP TAR DNA binding protein
TBC1D16 TBC1 domain family, member 16
TMEM14A transmembrane protein 14A
TSPAN8 tetraspanin 8
TXLNA taxilin alpha
USP48 ubiquitin specific peptidase 48
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF185 zinc finger protein 185 (LIM domain)