BRD-K68185022_Ursolic Acid_A549_24.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K68185022_Ursolic Acid_A549_24.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
AZU1 azurocidin 1
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL6 interleukin 6
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MMP1 matrix metallopeptidase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNIP1 TNFAIP3 interacting protein 1
TP53BP2 tumor protein p53 binding protein 2
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA7 annexin A7
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C4ORF27 chromosome 4 open reading frame 27
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CHEK2 checkpoint kinase 2
CMC2 C-x(9)-C motif containing 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYZ crystallin, zeta (quinone reductase)
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNA2 DNA replication helicase/nuclease 2
FCGBP Fc fragment of IgG binding protein
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FXYD2 FXYD domain containing ion transport regulator 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HADH hydroxyacyl-CoA dehydrogenase
HGD homogentisate 1,2-dioxygenase
HLTF helicase-like transcription factor
HMGN3 high mobility group nucleosomal binding domain 3
HOPX HOP homeobox
HSDL2 hydroxysteroid dehydrogenase like 2
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF14 kinesin family member 14
KRT10 keratin 10, type I
LBH limb bud and heart development
LBR lamin B receptor
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKSL1 MARCKS-like 1
MMD monocyte to macrophage differentiation-associated
MPHOSPH9 M-phase phosphoprotein 9
MPZL1 myelin protein zero-like 1
MRPS16 mitochondrial ribosomal protein S16
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NTS neurotensin
NUP210 nucleoporin 210kDa
PEG10 paternally expressed 10
PFN2 profilin 2
PLK1 polo-like kinase 1
PLS1 plastin 1
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
SEPHS1 selenophosphate synthetase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGPL1 sphingosine-1-phosphate lyase 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRA13 stimulated by retinoic acid 13
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN6 tetraspanin 6
TUBA4A tubulin, alpha 4a
UBE2A ubiquitin-conjugating enzyme E2A
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UPK1B uroplakin 1B
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VAV3 vav 3 guanine nucleotide exchange factor
VRK1 vaccinia related kinase 1