BRD-K68185022_Ursolic Acid_A375_24.0_h_70.07_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K68185022_Ursolic Acid_A375_24.0_h_70.07_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASS1 argininosuccinate synthase 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPAS1 endothelial PAS domain protein 1
FTH1 ferritin, heavy polypeptide 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA9 heat shock 70kDa protein 9 (mortalin)
ICAM1 intercellular adhesion molecule 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0226L KIAA0226-like
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCG5 secretogranin V
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC24D SEC24 family member D
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
CTSC cathepsin C
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECI2 enoyl-CoA delta isomerase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMGN3 high mobility group nucleosomal binding domain 3
ITGA6 integrin, alpha 6
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
MAP7 microtubule-associated protein 7
MSRB2 methionine sulfoxide reductase B2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PBK PDZ binding kinase
PON2 paraoxonase 2
SEPP1 selenoprotein P, plasma, 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A4RG SLC2A4 regulator
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TAGLN transgelin
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
Funding