BRD-K68174511_torin-2_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

342 genes differentially expressed following the BRD-K68174511_torin-2_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABHD4 abhydrolase domain containing 4
ADAM10 ADAM metallopeptidase domain 10
AGR2 anterior gradient 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP32 Rho GTPase activating protein 32
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BACE2 beta-site APP-cleaving enzyme 2
BCAS1 breast carcinoma amplified sequence 1
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CAPN3 calpain 3, (p94)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK12 cyclin-dependent kinase 12
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN4 claudin 4
CLMN calmin (calponin-like, transmembrane)
COBL cordon-bleu WH2 repeat protein
CST1 cystatin SN
CTH cystathionine gamma-lyase
CTSL cathepsin L
CYB5R1 cytochrome b5 reductase 1
DDIT3 DNA-damage-inducible transcript 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EFTUD1 elongation factor Tu GTP binding domain containing 1
EGF epidermal growth factor
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EXPH5 exophilin 5
FAM102A family with sequence similarity 102, member A
FGF13 fibroblast growth factor 13
FKBP14 FK506 binding protein 14, 22 kDa
FMOD fibromodulin
FXR1 fragile X mental retardation, autosomal homolog 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCC2 GRIP and coiled-coil domain containing 2
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPR137B G protein-coupled receptor 137B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRAMD1C GRAM domain containing 1C
GRB7 growth factor receptor-bound protein 7
GSAP gamma-secretase activating protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOOK2 hook microtubule-tethering protein 2
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
ICA1 islet cell autoantigen 1, 69kDa
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM3A lysine (K)-specific demethylase 3A
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LAMA3 laminin, alpha 3
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOC100272216 uncharacterized LOC100272216
LRRC16A leucine rich repeat containing 16A
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MGLL monoglyceride lipase
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NPAS2 neuronal PAS domain protein 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PCDH9 protocadherin 9
PDCD6 programmed cell death 6
PDE8A phosphodiesterase 8A
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRPF3 pre-mRNA processing factor 3
PRSS8 protease, serine, 8
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RIOK3 RIO kinase 3
RPL36 ribosomal protein L36
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC44A4 solute carrier family 44, member 4
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYT17 synaptotagmin XVII
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMC5 transmembrane channel-like 5
TMEM63A transmembrane protein 63A
TMEM87A transmembrane protein 87A
TOM1L1 target of myb1 (chicken)-like 1
TOX3 TOX high mobility group box family member 3
TPST2 tyrosylprotein sulfotransferase 2
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TSG101 tumor susceptibility 101
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMAT3 zinc finger, matrin-type 3
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP1 aquaporin 1 (Colton blood group)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKLF chemokine-like factor
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL4A6 collagen, type IV, alpha 6
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DNM1L dynamin 1-like
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FOXM1 forkhead box M1
FXYD6 FXYD domain containing ion transport regulator 6
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPX3 glutathione peroxidase 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLF hepatic leukemia factor
HMGB1 high mobility group box 1
HMGN2 high mobility group nucleosomal binding domain 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LMNB1 lamin B1
LMNB2 lamin B2
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LTF lactotransferrin
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MED21 mediator complex subunit 21
MGP matrix Gla protein
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAM1 neural cell adhesion molecule 1
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NFIB nuclear factor I/B
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG10 paternally expressed 10
PFAS phosphoribosylformylglycinamidine synthase
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRMT1 protein arginine methyltransferase 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RCAN2 regulator of calcineurin 2
RFC3 replication factor C (activator 1) 3, 38kDa
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SAMHD1 SAM domain and HD domain 1
SAP30 Sin3A-associated protein, 30kDa
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRMT5 tRNA methyltransferase 5
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein