BRD-K68174511_torin-2_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K68174511_torin-2_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AURKB aurora kinase B
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
CHEK2 checkpoint kinase 2
CREM cAMP responsive element modulator
CTSK cathepsin K
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM134B family with sequence similarity 134, member B
FNBP4 formin binding protein 4
GDF15 growth differentiation factor 15
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB10 growth factor receptor-bound protein 10
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
ISLR immunoglobulin superfamily containing leucine-rich repeat
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KIAA0753 KIAA0753
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT81 keratin 81, type II
LACTB2 lactamase, beta 2
LGALS4 lectin, galactoside-binding, soluble, 4
LPIN1 lipin 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MX2 MX dynamin-like GTPase 2
MXRA5 matrix-remodelling associated 5
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
NFIB nuclear factor I/B
NPC1 Niemann-Pick disease, type C1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PDE4DIP phosphodiesterase 4D interacting protein
PHF11 PHD finger protein 11
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PLAGL1 pleiomorphic adenoma gene-like 1
PRUNE2 prune homolog 2 (Drosophila)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D15 TBC1 domain family, member 15
TM4SF4 transmembrane 4 L six family member 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANO1 anoctamin 1, calcium activated chloride channel
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATXN1 ataxin 1
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CBR3 carbonyl reductase 3
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKAP4 cytoskeleton-associated protein 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FST follistatin
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JAG1 jagged 1
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
LEPROTL1 leptin receptor overlapping transcript-like 1
LRRN3 leucine rich repeat neuronal 3
LTF lactotransferrin
MAOA monoamine oxidase A
MCL1 myeloid cell leukemia 1
MFAP3L microfibrillar-associated protein 3-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MNDA myeloid cell nuclear differentiation antigen
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NAV3 neuron navigator 3
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OXTR oxytocin receptor
PCDH7 protocadherin 7
PFN2 profilin 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN1 reticulon 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOBP sine oculis binding protein homolog (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TGFB1 transforming growth factor, beta 1
THAP11 THAP domain containing 11
TMEM158 transmembrane protein 158 (gene/pseudogene)
USP46 ubiquitin specific peptidase 46
VAMP3 vesicle-associated membrane protein 3
VIPR1 vasoactive intestinal peptide receptor 1
WNT5A wingless-type MMTV integration site family, member 5A