BRD-K68174511_torin-2_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K68174511_torin-2_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
AMIGO2 adhesion molecule with Ig-like domain 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BECN1 beclin 1, autophagy related
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL1 cyclin L1
CCNL2 cyclin L2
CD44 CD44 molecule (Indian blood group)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
COCH cochlin
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHRS3 dehydrogenase/reductase (SDR family) member 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO4 forkhead box O4
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPM6B glycoprotein M6B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0368 KIAA0368
KIAA0430 KIAA0430
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LOC100272216 uncharacterized LOC100272216
LOC399491
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MPPED2 metallophosphoesterase domain containing 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NINL ninein-like
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPTN optineurin
PARP6 poly (ADP-ribose) polymerase family, member 6
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLSCR1 phospholipid scramblase 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAME preferentially expressed antigen in melanoma
PSPC1 paraspeckle component 1
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RBM5 RNA binding motif protein 5
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD5 SET domain containing 5
SH3YL1 SH3 and SYLF domain containing 1
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SP100 SP100 nuclear antigen
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TDRD7 tudor domain containing 7
TMEM45A transmembrane protein 45A
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF91 zinc finger protein 91
ZSWIM8 zinc finger, SWIM-type containing 8

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADAM9 ADAM metallopeptidase domain 9
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOC aldolase C, fructose-bisphosphate
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRCA1 breast cancer 1, early onset
C6ORF62 chromosome 6 open reading frame 62
CAPN1 calpain 1, (mu/I) large subunit
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN2 centrin, EF-hand protein, 2
COL14A1 collagen, type XIV, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSH cathepsin H
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHFR dihydrofolate reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4E eukaryotic translation initiation factor 4E
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GRK5 G protein-coupled receptor kinase 5
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGA2 high mobility group AT-hook 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB8 heat shock 22kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KRT13 keratin 13, type I
LAGE3 L antigen family, member 3
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MFAP4 microfibrillar-associated protein 4
MREG melanoregulin
MRPL12 mitochondrial ribosomal protein L12
MRPS14 mitochondrial ribosomal protein S14
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NOTCH2 notch 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDX4 peroxiredoxin 4
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
THAP11 THAP domain containing 11
TM7SF2 transmembrane 7 superfamily member 2
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TYMS thymidylate synthetase
UBE2N ubiquitin-conjugating enzyme E2N
VRK1 vaccinia related kinase 1