BRD-K68174511_torin-2_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K68174511_torin-2_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CGA glycoprotein hormones, alpha polypeptide
CRIP1 cysteine-rich protein 1 (intestinal)
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
EFNA1 ephrin-A1
FNTA farnesyltransferase, CAAX box, alpha
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBP1 HMG-box transcription factor 1
HMGB2 high mobility group box 2
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KIAA0907 KIAA0907
KIF14 kinesin family member 14
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LOC100272216 uncharacterized LOC100272216
LY6E lymphocyte antigen 6 complex, locus E
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PNKP polynucleotide kinase 3'-phosphatase
PSPC1 paraspeckle component 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC35F2 solute carrier family 35, member F2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADRB2 adrenoceptor beta 2, surface
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHEK1 checkpoint kinase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CPB1 carboxypeptidase B1 (tissue)
CRCT1 cysteine-rich C-terminal 1
CSTA cystatin A (stefin A)
CTSC cathepsin C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EREG epiregulin
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
F3 coagulation factor III (thromboplastin, tissue factor)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAS GNAS complex locus
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
ISOC1 isochorismatase domain containing 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
MAT2A methionine adenosyltransferase II, alpha
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
TACSTD2 tumor-associated calcium signal transducer 2
THAP11 THAP domain containing 11
THBS1 thrombospondin 1
WT1 Wilms tumor 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2