BRD-K68174511_torin-2_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

232 genes differentially expressed following the BRD-K68174511_torin-2_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACACB acetyl-CoA carboxylase beta
AMDHD2 amidohydrolase domain containing 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA1 annexin A1
ARG1 arginase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF4 activating transcription factor 4
BAG1 BCL2-associated athanogene
BRD8 bromodomain containing 8
BTN3A2 butyrophilin, subfamily 3, member A2
C5 complement component 5
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL2 cyclin L2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSAD cysteine sulfinic acid decarboxylase
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GNLY granulysin
GPATCH8 G patch domain containing 8
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JOSD1 Josephin domain containing 1
KDSR 3-ketodihydrosphingosine reductase
KIAA0430 KIAA0430
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KYNU kynureninase
LAMA3 laminin, alpha 3
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MCOLN1 mucolipin 1
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKG7 natural killer cell granule protein 7
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NSUN5 NOP2/Sun domain family, member 5
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NSUN5P2 NOP2/Sun domain family, member 5 pseudogene 2
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL1A oxysterol binding protein-like 1A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP6 poly (ADP-ribose) polymerase family, member 6
PAXBP1 PAX3 and PAX7 binding protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PILRB paired immunoglobin-like type 2 receptor beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPAP2C phosphatidic acid phosphatase type 2C
PPOX protoporphyrinogen oxidase
PSPC1 paraspeckle component 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC35E2B solute carrier family 35, member E2B
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
TBC1D15 TBC1 domain family, member 15
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGIF1 TGFB-induced factor homeobox 1
TMEM140 transmembrane protein 140
TPBG trophoblast glycoprotein
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UPP1 uridine phosphorylase 1
VAT1 vesicle amine transport 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF266 zinc finger protein 266
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK4 adenylate kinase 4
ARG2 arginase 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BHMT2 betaine--homocysteine S-methyltransferase 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CD47 CD47 molecule
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CNN1 calponin 1, basic, smooth muscle
CTSC cathepsin C
CTSZ cathepsin Z
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGF epidermal growth factor
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4E eukaryotic translation initiation factor 4E
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FERMT2 fermitin family member 2
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
ITM2C integral membrane protein 2C
KAZN kazrin, periplakin interacting protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
MAGED1 melanoma antigen family D1
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2 notch 2
NPR3 natriuretic peptide receptor 3
NRCAM neuronal cell adhesion molecule
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHACTR2 phosphatase and actin regulator 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX1 peroxiredoxin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB1A RAB1A, member RAS oncogene family
RRBP1 ribosome binding protein 1
RSU1 Ras suppressor protein 1
S100A10 S100 calcium binding protein A10
SCARB1 scavenger receptor class B, member 1
SDC2 syndecan 2
SFPQ splicing factor proline/glutamine-rich
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORD sorbitol dehydrogenase
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SQLE squalene epoxidase
TCF4 transcription factor 4
TFRC transferrin receptor
THBS1 thrombospondin 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED9 transmembrane emp24 protein transport domain containing 9
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TRAPPC3 trafficking protein particle complex 3
TTC39A tetratricopeptide repeat domain 39A
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UXS1 UDP-glucuronate decarboxylase 1
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1