BRD-K68174511_torin-2_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

280 genes differentially expressed following the BRD-K68174511_torin-2_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AHNAK2 AHNAK nucleoprotein 2
AKAP8 A kinase (PRKA) anchor protein 8
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANGPT1 angiopoietin 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BACE2 beta-site APP-cleaving enzyme 2
BIK BCL2-interacting killer (apoptosis-inducing)
C19ORF66 chromosome 19 open reading frame 66
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CAPN3 calpain 3, (p94)
CAPRIN2 caprin family member 2
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNL2 cyclin L2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK12 cyclin-dependent kinase 12
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COMP cartilage oligomeric matrix protein
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTH cystathionine gamma-lyase
CTSA cathepsin A
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFHC1 EF-hand domain (C-terminal) containing 1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF4B eukaryotic translation initiation factor 4B
ERP29 endoplasmic reticulum protein 29
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FN1 fibronectin 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSDMB gasdermin B
GSE1 Gse1 coiled-coil protein
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOOK2 hook microtubule-tethering protein 2
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0753 KIAA0753
KIAA0907 KIAA0907
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LOC399491
LONP2 lon peptidase 2, peroxisomal
LPIN1 lipin 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MSLN mesothelin
MXI1 MAX interactor 1, dimerization protein
MZF1 myeloid zinc finger 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPAS2 neuronal PAS domain protein 2
NPC1 Niemann-Pick disease, type C1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NSUN5 NOP2/Sun domain family, member 5
OFD1 oral-facial-digital syndrome 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARP6 poly (ADP-ribose) polymerase family, member 6
PCBP2 poly(rC) binding protein 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRL platelet-derived growth factor receptor-like
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RABGGTB Rab geranylgeranyltransferase, beta subunit
RBKS ribokinase
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
RUFY2 RUN and FYVE domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3YL1 SH3 and SYLF domain containing 1
SLC35E2B solute carrier family 35, member E2B
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPG11 spastic paraplegia 11 (autosomal recessive)
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI2 tissue factor pathway inhibitor 2
THBS3 thrombospondin 3
TMEM63A transmembrane protein 63A
TOB1 transducer of ERBB2, 1
TOM1L1 target of myb1 (chicken)-like 1
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC6A trafficking protein particle complex 6A
TRIB3 tribbles pseudokinase 3
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TSTA3 tissue specific transplantation antigen P35B
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP34 ubiquitin specific peptidase 34
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VNN1 vanin 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8
WDR19 WD repeat domain 19
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND2 cyclin D2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CSTA cystatin A (stefin A)
CYR61 cysteine-rich, angiogenic inducer, 61
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ECI2 enoyl-CoA delta isomerase 2
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
EMP2 epithelial membrane protein 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GSTA1 glutathione S-transferase alpha 1
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HSPA14 heat shock 70kDa protein 14
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LMNB1 lamin B1
LMNB2 lamin B2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1F metallothionein 1F
MT1X metallothionein 1X
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PBX1 pre-B-cell leukemia homeobox 1
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PODXL podocalyxin-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
RIN2 Ras and Rab interactor 2
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SEPHS1 selenophosphate synthetase 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
STOM stomatin
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
THBS1 thrombospondin 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPO thymopoietin
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WNT5A wingless-type MMTV integration site family, member 5A