BRD-K68174511_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K68174511_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCK3 aarF domain containing kinase 3
ADM adrenomedullin
AFF1 AF4/FMR2 family, member 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD10 ankyrin repeat domain 10
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASXL1 additional sex combs like transcriptional regulator 1
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BICC1 BicC family RNA binding protein 1
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CAPN3 calpain 3, (p94)
CCNG2 cyclin G2
CCNL1 cyclin L1
CLK4 CDC-like kinase 4
CRISP3 cysteine-rich secretory protein 3
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DENND5A DENN/MADD domain containing 5A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP1 dual specificity phosphatase 1
FAM129A family with sequence similarity 129, member A
FNBP4 formin binding protein 4
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HAL histidine ammonia-lyase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA2 heat shock 70kDa protein 2
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LOC399491
LOX lysyl oxidase
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALT1 MALT1 paracaspase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MED1 mediator complex subunit 1
MTA1 metastasis associated 1
MTCL1 microtubule crosslinking factor 1
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
PDLIM5 PDZ and LIM domain 5
PILRB paired immunoglobin-like type 2 receptor beta
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM39 RNA binding motif protein 39
RBM5 RNA binding motif protein 5
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SRSF7 serine/arginine-rich splicing factor 7
SYNJ2 synaptojanin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TCERG1 transcription elongation regulator 1
TKTL1 transketolase-like 1
UBAP2 ubiquitin associated protein 2
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WAC WW domain containing adaptor with coiled-coil
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AUTS2 autism susceptibility candidate 2
B3GNT1
C1QB complement component 1, q subcomponent, B chain
CADM1 cell adhesion molecule 1
CCND3 cyclin D3
CDC25A cell division cycle 25A
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLEC3B C-type lectin domain family 3, member B
COL6A2 collagen, type VI, alpha 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA5 defensin, alpha 5, Paneth cell-specific
DUSP22 dual specificity phosphatase 22
EMP2 epithelial membrane protein 2
FXYD6 FXYD domain containing ion transport regulator 6
GJA1 gap junction protein, alpha 1, 43kDa
GRB2 growth factor receptor-bound protein 2
GSTA1 glutathione S-transferase alpha 1
H3F3B H3 histone, family 3B (H3.3B)
HBB hemoglobin, beta
HN1 hematological and neurological expressed 1
ICT1 immature colon carcinoma transcript 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ISOC1 isochorismatase domain containing 1
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MID1 midline 1
MMP10 matrix metallopeptidase 10
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPS7 mitochondrial ribosomal protein S7
MXRA7 matrix-remodelling associated 7
MYL9 myosin, light chain 9, regulatory
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NELL2 NEL-like 2 (chicken)
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PID1 phosphotyrosine interaction domain containing 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POU2AF1 POU class 2 associating factor 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTN pleiotrophin
PXMP2 peroxisomal membrane protein 2, 22kDa
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SDC4 syndecan 4
SDF2L1 stromal cell-derived factor 2-like 1
SEPT9 septin 9
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STS steroid sulfatase (microsomal), isozyme S
SUMO2 small ubiquitin-like modifier 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM50B transmembrane protein 50B
TMSB15B thymosin beta 15B
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TUSC3 tumor suppressor candidate 3