BRD-K68143200_NSC 95397_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

353 genes differentially expressed following the BRD-K68143200_NSC 95397_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
C3 complement component 3
C7 complement component 7
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC68 coiled-coil domain containing 68
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD84 CD84 molecule
CD8A CD8a molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
COG7 component of oligomeric golgi complex 7
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRP C-reactive protein, pentraxin-related
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPCAM epithelial cell adhesion molecule
FAM49A family with sequence similarity 49, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FHOD3 formin homology 2 domain containing 3
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR3 formyl peptide receptor 3
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAL galanin/GMAP prepropeptide
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNLY granulysin
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
HABP2 hyaluronan binding protein 2
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL1B interleukin 1, beta
INSM1 insulinoma-associated 1
IPO13 importin 13
ITGA6 integrin, alpha 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
LPAR6 lysophosphatidic acid receptor 6
LST1 leukocyte specific transcript 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
LYZ lysozyme
MAPK10 mitogen-activated protein kinase 10
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
METTL1 methyltransferase like 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPZL2 myelin protein zero-like 2
NELL2 NEL-like 2 (chicken)
NES nestin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OBSL1 obscurin-like 1
ORC1 origin recognition complex, subunit 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCDH17 protocadherin 17
PCDH7 protocadherin 7
PCSK1 proprotein convertase subtilisin/kexin type 1
PERP PERP, TP53 apoptosis effector
PLVAP plasmalemma vesicle associated protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX13 sorting nexin 13
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSPN sarcospan
SST somatostatin
STEAP3 STEAP family member 3, metalloreductase
TBXA2R thromboxane A2 receptor
TDO2 tryptophan 2,3-dioxygenase
TERT telomerase reverse transcriptase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TREM2 triggering receptor expressed on myeloid cells 2
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TYROBP TYRO protein tyrosine kinase binding protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
XCL1 chemokine (C motif) ligand 1
XIST X inactive specific transcript (non-protein coding)
ZNF544 zinc finger protein 544
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACACA acetyl-CoA carboxylase alpha
ACSF2 acyl-CoA synthetase family member 2
ACSL1 acyl-CoA synthetase long-chain family member 1
AFF1 AF4/FMR2 family, member 1
AHCYL1 adenosylhomocysteinase-like 1
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANXA3 annexin A3
ANXA5 annexin A5
ANXA6 annexin A6
APOD apolipoprotein D
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
B3GNT1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD3 bromodomain containing 3
BST2 bone marrow stromal cell antigen 2
C14ORF1 chromosome 14 open reading frame 1
C16ORF45 chromosome 16 open reading frame 45
CCNF cyclin F
CCNG1 cyclin G1
CCNG2 cyclin G2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF2 CUGBP, Elav-like family member 2
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLINT1 clathrin interactor 1
CLU clusterin
CST3 cystatin C
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND5A DENN/MADD domain containing 5A
DHCR24 24-dehydrocholesterol reductase
DIAPH1 diaphanous-related formin 1
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EHD1 EH-domain containing 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A3 eukaryotic translation initiation factor 4A3
ENO1 enolase 1, (alpha)
EPN2 epsin 2
EVC Ellis van Creveld protein
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208A family with sequence similarity 208, member A
FASN fatty acid synthase
FBN1 fibrillin 1
FLNB filamin B, beta
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAS1 growth arrest-specific 1
GLDC glycine dehydrogenase (decarboxylating)
GOLGA7 golgin A7
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GRSF1 G-rich RNA sequence binding factor 1
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HLTF helicase-like transcription factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRF4 interferon regulatory factor 4
JADE1 jade family PHD finger 1
KANK2 KN motif and ankyrin repeat domains 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF1B kinesin family member 1B
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGED1 melanoma antigen family D1
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MPRIP myosin phosphatase Rho interacting protein
MSMO1 methylsterol monooxygenase 1
MTA1 metastasis associated 1
MTMR4 myotubularin related protein 4
MYLK myosin light chain kinase
N4BP2L2 NEDD4 binding protein 2-like 2
NFIB nuclear factor I/B
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NT5DC2 5'-nucleotidase domain containing 2
OXTR oxytocin receptor
PCGF2 polycomb group ring finger 2
PCM1 pericentriolar material 1
PCYOX1L prenylcysteine oxidase 1 like
PDIA5 protein disulfide isomerase family A, member 5
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKP phosphofructokinase, platelet
PGD phosphogluconate dehydrogenase
PGM1 phosphoglucomutase 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
QKI QKI, KH domain containing, RNA binding
RAB5A RAB5A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RHOA ras homolog family member A
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SAR1B secretion associated, Ras related GTPase 1B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24A SEC24 family member A
SECISBP2L SECIS binding protein 2-like
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPT11 septin 11
SEPT8 septin 8
SF1 splicing factor 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMC4 structural maintenance of chromosomes 4
SNX11 sorting nexin 11
SORBS3 sorbin and SH3 domain containing 3
SPOP speckle-type POZ protein
SPTAN1 spectrin, alpha, non-erythrocytic 1
STXBP1 syntaxin binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D5 TBC1 domain family, member 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMCO3 transmembrane and coiled-coil domains 3
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TOP2B topoisomerase (DNA) II beta 180kDa
TRAM2 translocation associated membrane protein 2
TSPYL4 TSPY-like 4
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase
USP48 ubiquitin specific peptidase 48
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WAC WW domain containing adaptor with coiled-coil
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24
ZEB2 zinc finger E-box binding homeobox 2
ZNF185 zinc finger protein 185 (LIM domain)