BRD-K68065987_MK-2206_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K68065987_MK-2206_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP32 Rho GTPase activating protein 32
C10ORF10 chromosome 10 open reading frame 10
C7 complement component 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHRDL1 chordin-like 1
CNN1 calponin 1, basic, smooth muscle
CST3 cystatin C
DARS aspartyl-tRNA synthetase
DCLK1 doublecortin-like kinase 1
ENAH enabled homolog (Drosophila)
EPS8 epidermal growth factor receptor pathway substrate 8
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INSIG1 insulin induced gene 1
KRT6B keratin 6B, type II
MFAP3L microfibrillar-associated protein 3-like
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
NFIB nuclear factor I/B
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPARG peroxisome proliferator-activated receptor gamma
PTGIS prostaglandin I2 (prostacyclin) synthase
RPL39L ribosomal protein L39-like
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SSPN sarcospan
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TGFBR3 transforming growth factor, beta receptor III
TMEM255A transmembrane protein 255A
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ANXA3 annexin A3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
EGR2 early growth response 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF10 Kruppel-like factor 10
MAT2A methionine adenosyltransferase II, alpha
NREP neuronal regeneration related protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SYBU syntabulin (syntaxin-interacting)
TMEM176B transmembrane protein 176B