BRD-K68065987_MK-2206_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K68065987_MK-2206_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ANXA4 annexin A4
APOD apolipoprotein D
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C7 complement component 7
CALHM2 calcium homeostasis modulator 2
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD8A CD8a molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CHN1 chimerin 1
CHN2 chimerin 2
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ETV1 ets variant 1
EVI2A ecotropic viral integration site 2A
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLRT2 fibronectin leucine rich transmembrane protein 2
GNLY granulysin
GRN granulin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
GZMK granzyme K (granzyme 3; tryptase II)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IDS iduronate 2-sulfatase
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP6 insulin-like growth factor binding protein 6
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAMP5 lysosomal-associated membrane protein family, member 5
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MDFIC MyoD family inhibitor domain containing
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MYRF myelin regulatory factor
NKG7 natural killer cell granule protein 7
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PRF1 perforin 1 (pore forming protein)
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB33A RAB33A, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
STOM stomatin
SYT1 synaptotagmin I
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TKT transketolase
TM4SF4 transmembrane 4 L six family member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
COL5A1 collagen, type V, alpha 1
CREB1 cAMP responsive element binding protein 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
GAL galanin/GMAP prepropeptide
JUNB jun B proto-oncogene
KRT13 keratin 13, type I
KRT15 keratin 15, type I
MYB v-myb avian myeloblastosis viral oncogene homolog
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
SDC2 syndecan 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOX9 SRY (sex determining region Y)-box 9
STAP2 signal transducing adaptor family member 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C