BRD-K67868012_PI-103_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

201 genes differentially expressed following the BRD-K67868012_PI-103_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCAS3 breast carcinoma amplified sequence 3
C14ORF159 chromosome 14 open reading frame 159
C6ORF48 chromosome 6 open reading frame 48
CANT1 calcium activated nucleotidase 1
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CRTAP cartilage associated protein
CSNK1A1 casein kinase 1, alpha 1
CST1 cystatin SN
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GRN granulin
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HBP1 HMG-box transcription factor 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IL10RB interleukin 10 receptor, beta
IRS1 insulin receptor substrate 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT6B K(lysine) acetyltransferase 6B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5B lysine (K)-specific demethylase 5B
KIAA0355 KIAA0355
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYLIP myosin regulatory light chain interacting protein
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NET1 neuroepithelial cell transforming 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RAP1GAP2 RAP1 GTPase activating protein 2
RGS10 regulator of G-protein signaling 10
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SESN1 sestrin 1
SLC22A18 solute carrier family 22, member 18
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC44A4 solute carrier family 44, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMC5 transmembrane channel-like 5
TMEM63A transmembrane protein 63A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPM2 tropomyosin 2 (beta)
TRAF5 TNF receptor-associated factor 5
TSPAN1 tetraspanin 1
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL4 acyl-CoA synthetase long-chain family member 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
C20ORF24 chromosome 20 open reading frame 24
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIT citron rho-interacting serine/threonine kinase
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COTL1 coactosin-like F-actin binding protein 1
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ITGB1BP1 integrin beta 1 binding protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LBR lamin B receptor
LMO3 LIM domain only 3 (rhombotin-like 2)
MAK16 MAK16 homolog (S. cerevisiae)
MALT1 MALT1 paracaspase
MAOB monoamine oxidase B
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY1R neuropeptide Y receptor Y1
P3H2 prolyl 3-hydroxylase 2
PARP2 poly (ADP-ribose) polymerase 2
PDE8B phosphodiesterase 8B
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCAN2 regulator of calcineurin 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCRG1 stimulator of chondrogenesis 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLBP stem-loop binding protein
SLC35F2 solute carrier family 35, member F2
SORBS1 sorbin and SH3 domain containing 1
SRM spermidine synthase
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM45A transmembrane protein 45A
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)