BRD-K67868012_PI-103_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K67868012_PI-103_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSF2 acyl-CoA synthetase family member 2
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMOTL2 angiomotin like 2
ANPEP alanyl (membrane) aminopeptidase
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM46A family with sequence similarity 46, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
JUP junction plakoglobin
KAT6B K(lysine) acetyltransferase 6B
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
KYNU kynureninase
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MAGED2 melanoma antigen family D2
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MVP major vault protein
MYO5C myosin VC
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PGAP3 post-GPI attachment to proteins 3
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRSS23 protease, serine, 23
PTPRO protein tyrosine phosphatase, receptor type, O
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNGR3 synaptogyrin 3
TCTA T-cell leukemia translocation altered
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TSC22D1 TSC22 domain family, member 1
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AMD1 adenosylmethionine decarboxylase 1
ATAD2 ATPase family, AAA domain containing 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG3 BTG family, member 3
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHEK1 checkpoint kinase 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HK2 hexokinase 2
HSPA14 heat shock 70kDa protein 14
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIAA0226L KIAA0226-like
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LMNB2 lamin B2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAMPT nicotinamide phosphoribosyltransferase
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PSMC3IP PSMC3 interacting protein
RFC3 replication factor C (activator 1) 3, 38kDa
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SESN1 sestrin 1
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
TFRC transferrin receptor
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase