BRD-K67868012_PI-103_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

326 genes differentially expressed following the BRD-K67868012_PI-103_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADIRF adipogenesis regulatory factor
AES amino-terminal enhancer of split
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP9A ATPase, class II, type 9A
ATRX alpha thalassemia/mental retardation syndrome X-linked
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CPD carboxypeptidase D
CREBL2 cAMP responsive element binding protein-like 2
CTSA cathepsin A
CTSD cathepsin D
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DCN decorin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F2R coagulation factor II (thrombin) receptor
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GM2A GM2 ganglioside activator
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRB10 growth factor receptor-bound protein 10
GRN granulin
GSN gelsolin
GSTZ1 glutathione S-transferase zeta 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
IDUA iduronidase, alpha-L-
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUP junction plakoglobin
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLHL24 kelch-like family member 24
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LTBP3 latent transforming growth factor beta binding protein 3
LXN latexin
MAN2B1 mannosidase, alpha, class 2B, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MSLN mesothelin
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL10 oxysterol binding protein-like 10
OSMR oncostatin M receptor
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZD2 PDZ domain containing 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLD3 phospholipase D family, member 3
PLXNB2 plexin B2
PNPLA2 patatin-like phospholipase domain containing 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPL periplakin
PRAF2 PRA1 domain family, member 2
PSAP prosaposin
PTK2B protein tyrosine kinase 2 beta
PTPRE protein tyrosine phosphatase, receptor type, E
RABAC1 Rab acceptor 1 (prenylated)
RNF103 ring finger protein 103
RPS27L ribosomal protein S27-like
RRAS related RAS viral (r-ras) oncogene homolog
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC38A2 solute carrier family 38, member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SYT17 synaptotagmin XVII
TCEAL4 transcription elongation factor A (SII)-like 4
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM59 transmembrane protein 59
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF160 zinc finger protein 160

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNE2 cyclin E2
CCNF cyclin F
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
COPS3 COP9 signalosome subunit 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
EFHD1 EF-hand domain family, member D1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAL galanin/GMAP prepropeptide
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
ILF2 interleukin enhancer binding factor 2
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MOCS2 molybdenum cofactor synthesis 2
MSX1 msh homeobox 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NRG1 neuregulin 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFAS phosphoribosylformylglycinamidine synthase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
PSMC3IP PSMC3 interacting protein
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PTGES3 prostaglandin E synthase 3 (cytosolic)
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD54L RAD54-like (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFWD3 ring finger and WD repeat domain 3
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDF2L1 stromal cell-derived factor 2-like 1
SERINC5 serine incorporator 5
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A46 solute carrier family 25, member 46
SMC1A structural maintenance of chromosomes 1A
SNAP25 synaptosomal-associated protein, 25kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STOML2 stomatin (EPB72)-like 2
SUB1 SUB1 homolog (S. cerevisiae)
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TMEM194A transmembrane protein 194A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX2 thioredoxin-related transmembrane protein 2
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VDAC3 voltage-dependent anion channel 3
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein