BRD-K67868012_PI-103_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

262 genes differentially expressed following the BRD-K67868012_PI-103_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK AHNAK nucleoprotein
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
AREG amphiregulin
ATM ATM serine/threonine kinase
BHLHE41 basic helix-loop-helix family, member e41
C6ORF48 chromosome 6 open reading frame 48
CALB1 calbindin 1, 28kDa
CAMLG calcium modulating ligand
CCDC92 coiled-coil domain containing 92
CD200 CD200 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CKB creatine kinase, brain
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL4A5 collagen, type IV, alpha 5
CREB1 cAMP responsive element binding protein 1
CYB561 cytochrome b561
CYBB cytochrome b-245, beta polypeptide
DIAPH2 diaphanous-related formin 2
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EID1 EP300 interacting inhibitor of differentiation 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
EML3 echinoderm microtubule associated protein like 3
ETHE1 ethylmalonic encephalopathy 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAR2 fatty acyl CoA reductase 2
FOXN3 forkhead box N3
FXR1 fragile X mental retardation, autosomal homolog 1
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD5 frizzled class receptor 5
GLTSCR2 glioma tumor suppressor candidate region gene 2
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMGA2 high mobility group AT-hook 2
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2R insulin-like growth factor 2 receptor
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRF6 interferon regulatory factor 6
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMA3 laminin, alpha 3
LEFTY1 left-right determination factor 1
LETMD1 LETM1 domain containing 1
LINC00341 long intergenic non-protein coding RNA 341
LMOD1 leiomodin 1 (smooth muscle)
LTA4H leukotriene A4 hydrolase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MLPH melanophilin
MME membrane metallo-endopeptidase
MTMR11 myotubularin related protein 11
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
MYO1D myosin ID
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCGF2 polycomb group ring finger 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PKP2 plakophilin 2
PLA2G16 phospholipase A2, group XVI
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNMA2 paraneoplastic Ma antigen 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
QARS glutaminyl-tRNA synthetase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIMP2 TIMP metallopeptidase inhibitor 2
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
VNN1 vanin 1
VWF von Willebrand factor
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CD69 CD69 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CIT citron rho-interacting serine/threonine kinase
CKAP2 cytoskeleton associated protein 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IARS isoleucyl-tRNA synthetase
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LMO4 LIM domain only 4
LPL lipoprotein lipase
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RNASEH2A ribonuclease H2, subunit A
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPG small nuclear ribonucleoprotein polypeptide G
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCL1A T-cell leukemia/lymphoma 1A
TFDP1 transcription factor Dp-1
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TXN thioredoxin
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein