BRD-K67868012_PI-103_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K67868012_PI-103_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADCY1 adenylate cyclase 1 (brain)
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASRGL1 asparaginase like 1
ATP9A ATPase, class II, type 9A
BEX4 brain expressed, X-linked 4
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCNI cyclin I
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLEC2B C-type lectin domain family 2, member B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSD cathepsin D
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EEF2 eukaryotic translation elongation factor 2
EIF2D eukaryotic translation initiation factor 2D
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF4B eukaryotic translation initiation factor 4B
ELOVL4 ELOVL fatty acid elongase 4
EPS8 epidermal growth factor receptor pathway substrate 8
EXOC1 exocyst complex component 1
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAP fibroblast activation protein, alpha
FAXDC2 fatty acid hydroxylase domain containing 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXO4 forkhead box O4
GATA3 GATA binding protein 3
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GRAMD1C GRAM domain containing 1C
GRN granulin
GSDMB gasdermin B
GSN gelsolin
H3F3B H3 histone, family 3B (H3.3B)
HAUS4 HAUS augmin-like complex, subunit 4
HEBP2 heme binding protein 2
HIST3H2A histone cluster 3, H2a
HMGA1 high mobility group AT-hook 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSM1 insulinoma-associated 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM5D lysine (K)-specific demethylase 5D
KLHDC2 kelch domain containing 2
LAMA4 laminin, alpha 4
LETMD1 LETM1 domain containing 1
LPAR6 lysophosphatidic acid receptor 6
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP2 microfibrillar-associated protein 2
MMP2 matrix metallopeptidase 2
MOXD1 monooxygenase, DBH-like 1
MPDZ multiple PDZ domain protein
MTMR11 myotubularin related protein 11
MYO1D myosin ID
N4BP2L1 NEDD4 binding protein 2-like 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PGLS 6-phosphogluconolactonase
PPARD peroxisome proliferator-activated receptor delta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PXMP2 peroxisomal membrane protein 2, 22kDa
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS10 regulator of G-protein signaling 10
RPL22 ribosomal protein L22
RPL36 ribosomal protein L36
RPS9 ribosomal protein S9
SCGB1D2 secretoglobin, family 1D, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TCEA2 transcription elongation factor A (SII), 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VAT1 vesicle amine transport 1
VCAN versican
WDR13 WD repeat domain 13
WDR19 WD repeat domain 19
YBX3 Y box binding protein 3
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGRG1 adhesion G protein-coupled receptor G1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX15B arachidonate 15-lipoxygenase, type B
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CDC42 cell division cycle 42
CETN2 centrin, EF-hand protein, 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EAF2 ELL associated factor 2
ECI2 enoyl-CoA delta isomerase 2
EGF epidermal growth factor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
FAM162A family with sequence similarity 162, member A
FAM98A family with sequence similarity 98, member A
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GSPT1 G1 to S phase transition 1
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HILPDA hypoxia inducible lipid droplet-associated
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER2 homer scaffolding protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
IRF4 interferon regulatory factor 4
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
LRRC59 leucine rich repeat containing 59
LSM1 LSM1, U6 small nuclear RNA associated
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAK16 MAK16 homolog (S. cerevisiae)
MAL mal, T-cell differentiation protein
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINA MYC induced nuclear antigen
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL42 mitochondrial ribosomal protein L42
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAK1IP1 PAK1 interacting protein 1
PAX8 paired box 8
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDCD10 programmed cell death 10
PDIA3 protein disulfide isomerase family A, member 3
PDIA5 protein disulfide isomerase family A, member 5
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PGM3 phosphoglucomutase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSENEN presenilin enhancer gamma secretase subunit
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RPP40 ribonuclease P/MRP 40kDa subunit
RRAGD Ras-related GTP binding D
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SELT selenoprotein T
SERP1 stress-associated endoplasmic reticulum protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SORD sorbitol dehydrogenase
SPRR1A small proline-rich protein 1A
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SUB1 SUB1 homolog (S. cerevisiae)
TARS threonyl-tRNA synthetase
TFB2M transcription factor B2, mitochondrial
TFRC transferrin receptor
THY1 Thy-1 cell surface antigen
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMED9 transmembrane emp24 protein transport domain containing 9
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
TRAPPC3 trafficking protein particle complex 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WSB2 WD repeat and SOCS box containing 2
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase