BRD-K67860401_GSK-3b Inhibitor VIII_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

335 genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA9 annexin A9
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF56 chromosome 1 open reading frame 56
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD200 CD200 molecule
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CECR1 cat eye syndrome chromosome region, candidate 1
CFDP1 craniofacial development protein 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DIO1 deiodinase, iodothyronine, type I
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
EFHD1 EF-hand domain family, member D1
EIF4A1 eukaryotic translation initiation factor 4A1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ESM1 endothelial cell-specific molecule 1
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FRY furry homolog (Drosophila)
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD1 frizzled class receptor 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA4 golgin A4
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GUSBP3 glucuronidase, beta pseudogene 3
H2AFV H2A histone family, member V
HBB hemoglobin, beta
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
HOXB2 homeobox B2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
IRF9 interferon regulatory factor 9
ISOC1 isochorismatase domain containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD12 potassium channel tetramerization domain containing 12
KIAA1467 KIAA1467
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRMP lymphoid-restricted membrane protein
MAN1A1 mannosidase, alpha, class 1A, member 1
MB myoglobin
MED13L mediator complex subunit 13-like
MEIS2 Meis homeobox 2
MPZL2 myelin protein zero-like 2
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
NARFL nuclear prelamin A recognition factor-like
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NFE2L3 nuclear factor, erythroid 2-like 3
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
NVL nuclear VCP-like
P3H2 prolyl 3-hydroxylase 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXNB2 plexin B2
PMM2 phosphomannomutase 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRPF4B pre-mRNA processing factor 4B
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RAD21 RAD21 homolog (S. pombe)
RAI14 retinoic acid induced 14
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIMS3 regulating synaptic membrane exocytosis 3
RNASE6 ribonuclease, RNase A family, k6
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNH1 ribonuclease/angiogenin inhibitor 1
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMPX small muscle protein, X-linked
SOX11 SRY (sex determining region Y)-box 11
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STON1 stonin 1
SULF1 sulfatase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCTA T-cell leukemia translocation altered
TFEC transcription factor EC
THBS2 thrombospondin 2
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
USP34 ubiquitin specific peptidase 34
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF395 zinc finger protein 395
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACLY ATP citrate lyase
AGR2 anterior gradient 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA5 annexin A5
APLP2 amyloid beta (A4) precursor-like protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG1 BCL2-associated athanogene
BAG2 BCL2-associated athanogene 2
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BZW1 basic leucine zipper and W2 domains 1
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHL1 cell adhesion molecule L1-like
CHMP1B charged multivesicular body protein 1B
CHPT1 choline phosphotransferase 1
CLGN calmegin
CLU clusterin
COL9A3 collagen, type IX, alpha 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DYNLL1 dynein, light chain, LC8-type 1
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM222B family with sequence similarity 222, member B
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GOLGA7 golgin A7
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGA1 high mobility group AT-hook 1
HN1 hematological and neurological expressed 1
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
HSPB11 heat shock protein family B (small), member 11
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIF14 kinesin family member 14
KLF5 Kruppel-like factor 5 (intestinal)
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
LAMC2 laminin, gamma 2
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTS neurotensin
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PEBP1 phosphatidylethanolamine binding protein 1
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLS3 plastin 3
PLTP phospholipid transfer protein
PMEPA1 prostate transmembrane protein, androgen induced 1
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCZ protein kinase C, zeta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOF ras homolog family member F (in filopodia)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPN2 ribophorin II
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SECISBP2L SECIS binding protein 2-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SMAD2 SMAD family member 2
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TLE3 transducin-like enhancer of split 3
TM4SF1 transmembrane 4 L six family member 1
TMEM106B transmembrane protein 106B
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TSC22D4 TSC22 domain family, member 4
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TYRP1 tyrosinase-related protein 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WBSCR22 Williams Beuren syndrome chromosome region 22
YBX3 Y box binding protein 3
ZCCHC24 zinc finger, CCHC domain containing 24