BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAM9 ADAM metallopeptidase domain 9
APOC1 apolipoprotein C-I
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCL2L1 BCL2-like 1
BID BH3 interacting domain death agonist
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLU clusterin
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
FAM60A family with sequence similarity 60, member A
FCGBP Fc fragment of IgG binding protein
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL1RN interleukin 1 receptor antagonist
IPO13 importin 13
ISOC1 isochorismatase domain containing 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KCTD12 potassium channel tetramerization domain containing 12
LAPTM5 lysosomal protein transmembrane 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDRG1 N-myc downstream regulated 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NVL nuclear VCP-like
OPN3 opsin 3
PALLD palladin, cytoskeletal associated protein
PARM1 prostate androgen-regulated mucin-like protein 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMM2 phosphomannomutase 2
PNMA2 paraneoplastic Ma antigen 2
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SHB Src homology 2 domain containing adaptor protein B
SPARCL1 SPARC-like 1 (hevin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
STAB1 stabilin 1
TARP TCR gamma alternate reading frame protein
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
AK1 adenylate kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ANO1 anoctamin 1, calcium activated chloride channel
ARL4A ADP-ribosylation factor-like 4A
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
C8ORF4 chromosome 8 open reading frame 4
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHMP1B charged multivesicular body protein 1B
CHMP6 charged multivesicular body protein 6
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKAP4 cytoskeleton-associated protein 4
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DACT1 dishevelled-binding antagonist of beta-catenin 1
ECI2 enoyl-CoA delta isomerase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FBLN1 fibulin 1
FBN1 fibrillin 1
FBXO9 F-box protein 9
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GPC3 glypican 3
GPM6B glycoprotein M6B
HDAC6 histone deacetylase 6
HMGN3 high mobility group nucleosomal binding domain 3
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
ITGA6 integrin, alpha 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
MFAP2 microfibrillar-associated protein 2
MGP matrix Gla protein
MIA melanoma inhibitory activity
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYH10 myosin, heavy chain 10, non-muscle
NDN necdin, melanoma antigen (MAGE) family member
NEBL nebulette
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PDZRN3 PDZ domain containing ring finger 3
PIP prolactin-induced protein
PLEC plectin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SORBS1 sorbin and SH3 domain containing 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
SYNM synemin, intermediate filament protein
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TMEM5 transmembrane protein 5
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)