BRD-K67808578_1391-0741_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K67808578_1391-0741_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
APOD apolipoprotein D
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CCR7 chemokine (C-C motif) receptor 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IER5 immediate early response 5
IL6 interleukin 6
KAZN kazrin, periplakin interacting protein
KYNU kynureninase
LAMB1 laminin, beta 1
LRP4 low density lipoprotein receptor-related protein 4
MATN2 matrilin 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PIR pirin (iron-binding nuclear protein)
PPARG peroxisome proliferator-activated receptor gamma
PTX3 pentraxin 3, long
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RHOBTB3 Rho-related BTB domain containing 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SMAD3 SMAD family member 3
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASPN asporin
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPM centromere protein M
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
COL1A2 collagen, type I, alpha 2
DEPTOR DEP domain containing MTOR-interacting protein
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
JCHAIN joining chain of multimeric IgA and IgM
KIF11 kinesin family member 11
KIF2C kinesin family member 2C
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NMU neuromedin U
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
POSTN periostin, osteoblast specific factor
RAB31 RAB31, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASE4 ribonuclease, RNase A family, 4
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
SMC2 structural maintenance of chromosomes 2
SNX7 sorting nexin 7
SOX9 SRY (sex determining region Y)-box 9
SPTSSA serine palmitoyltransferase, small subunit A
SULF1 sulfatase 1
TMEM106C transmembrane protein 106C
TOP2A topoisomerase (DNA) II alpha 170kDa
TRPS1 trichorhinophalangeal syndrome I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein