BRD-K67808578_1391-0741_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K67808578_1391-0741_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAM17 ADAM metallopeptidase domain 17
AHNAK AHNAK nucleoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CD52 CD52 molecule
CD9 CD9 molecule
CTSE cathepsin E
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
EI24 etoposide induced 2.4
EPAS1 endothelial PAS domain protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FILIP1L filamin A interacting protein 1-like
GAS6 growth arrest-specific 6
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8B golgin A8 family, member B
GPX2 glutathione peroxidase 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KLF4 Kruppel-like factor 4 (gut)
KRT20 keratin 20, type I
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAP1B microtubule-associated protein 1B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OBSL1 obscurin-like 1
OPTN optineurin
PBX3 pre-B-cell leukemia homeobox 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFTN1 raftlin, lipid raft linker 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RUNX1 runt-related transcription factor 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC35F2 solute carrier family 35, member F2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SULF1 sulfatase 1
SYNPO synaptopodin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNIP1 TNFAIP3 interacting protein 1
TP53I3 tumor protein p53 inducible protein 3
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VNN1 vanin 1
WDR45 WD repeat domain 45

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
ATF1 activating transcription factor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHSY1 chondroitin sulfate synthase 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CMC2 C-x(9)-C motif containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FGF13 fibroblast growth factor 13
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GRB14 growth factor receptor-bound protein 14
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
NCAPG2 non-SMC condensin II complex, subunit G2
NET1 neuroepithelial cell transforming 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRMT1 protein arginine methyltransferase 1
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
RRM2 ribonucleotide reductase M2
S100A1 S100 calcium binding protein A1
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SPAG5 sperm associated antigen 5
SRGN serglycin
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCAF1 TRPM8 channel-associated factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZWINT ZW10 interacting kinetochore protein
Funding