BRD-K67808578_1391-0741_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K67808578_1391-0741_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNA1 cyclin A1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CST1 cystatin SN
DDIT4 DNA-damage-inducible transcript 4
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPRS glutamyl-prolyl-tRNA synthetase
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
KRT8 keratin 8, type II
LRMP lymphoid-restricted membrane protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMOX spermine oxidase
STK26 serine/threonine protein kinase 26
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TST thiosulfate sulfurtransferase (rhodanese)
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CDC42 cell division cycle 42
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EPHA3 EPH receptor A3
FOLR1 folate receptor 1 (adult)
HSPA1A heat shock 70kDa protein 1A
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
LY6D lymphocyte antigen 6 complex, locus D
MTSS1 metastasis suppressor 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
PARP2 poly (ADP-ribose) polymerase 2
PBX3 pre-B-cell leukemia homeobox 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPL periplakin
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SORBS2 sorbin and SH3 domain containing 2
SPEN spen family transcriptional repressor
SPRR3 small proline-rich protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10