BRD-K67742177_(4-(2,5-di(furan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)(furan-3-yl)methanone KUC106884N_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K67742177_(4-(2,5-di(furan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl)piperazin-1-yl)(furan-3-yl)methanone KUC106884N_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHR aryl hydrocarbon receptor
ARG2 arginase 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A2 collagen, type I, alpha 2
DDIT4 DNA-damage-inducible transcript 4
FHL1 four and a half LIM domains 1
GBP2 guanylate binding protein 2, interferon-inducible
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLIT2 slit homolog 2 (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
TF transferrin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TOX3 TOX high mobility group box family member 3

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AQP3 aquaporin 3 (Gill blood group)
ASPN asporin
CD83 CD83 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
DLK1 delta-like 1 homolog (Drosophila)
EVL Enah/Vasp-like
FABP4 fatty acid binding protein 4, adipocyte
FASTKD5 FAST kinase domains 5
FKBP1B FK506 binding protein 1B, 12.6 kDa
GPI glucose-6-phosphate isomerase
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ISG15 ISG15 ubiquitin-like modifier
ISLR immunoglobulin superfamily containing leucine-rich repeat
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
MCUR1 mitochondrial calcium uniporter regulator 1
METRN meteorin, glial cell differentiation regulator
MMP11 matrix metallopeptidase 11
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCD protein kinase C, delta
PUF60 poly-U binding splicing factor 60KDa
RBP1 retinol binding protein 1, cellular
RGS4 regulator of G-protein signaling 4